Topical Nano and Microemulsions for Skin Delivery

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2017 Sep 22

PMID 28934172

Citations 88

Authors

Christofori M R R Nastiti

Thellie Ponto

Eman Abd

Jeffrey E Grice

Heather A E Benson

Michael S Roberts

Affiliations

Soon will be listed here.

Abstract

Nanosystems such as microemulsions (ME) and nanoemulsions (NE) offer considerable opportunities for targeted drug delivery to and via the skin. ME and NE are stable colloidal systems composed of oil and water, stabilised by a mixture of surfactants and cosurfactants, that have received particular interest as topical skin delivery systems. There is considerable scope to manipulate the formulation components and characteristics to achieve optimal bioavailability and minimal skin irritancy. This includes the incorporation of established chemical penetration enhancers to fluidize the stratum corneum lipid bilayers, thus reducing the primary skin barrier and increasing permeation. This review discusses nanosystems with utility in skin delivery and focuses on the composition and characterization of ME and NE for topical and transdermal delivery. The mechanism of skin delivery across the stratum corneum and via hair follicles is reviewed with particular focus on the influence of formulation.

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