Antinociceptive and 'neurotoxic' Actions of Somatostatin in Rat Spinal Cord After Intrathecal Administration

Overview

Journal Pain

Specialties Neurology
Psychiatry

Date 1988 Jan 1

PMID 2893326

Citations 11

Authors

Peter Mollenholt

Claes Post

Narinder Rawal

Jacob Freedman

Tomas Hokfelt

Ivar Paulsson

Affiliations

Soon will be listed here.

Abstract

In the present investigation, the antinociceptive effect of somatostatin (SST) was assessed after intrathecal injection in rats. It was found that the peptide caused antinociception, hind limb paralysis and neuronal damage of the spinal cord in a dose-dependent manner. The threshold dose for antinociception was lower (approximately 10 micrograms) than that (approximately 30 micrograms) giving rise to chronic motor impairment associated with necrotic changes and loss of an immunohistochemical marker for motoneurons in the spinal cord. It is concluded that the 'neurotoxic' potential of SST should be considered in further clinical trials.

Citing Articles

Somatostatin and its 2A receptor in dorsal root ganglia and dorsal horn of mouse and human: expression, trafficking and possible role in pain.

Shi T, Xiang Q, Zhang M, Barde S, Kai-Larsen Y, Fried K Mol Pain. 2014; 10:12.

PMID: 24521084 PMC: 3943448. DOI: 10.1186/1744-8069-10-12.

A quantitative study of inhibitory interneurons in laminae I-III of the mouse spinal dorsal horn.

Polgar E, Durrieux C, Hughes D, Todd A PLoS One. 2013; 8(10):e78309.

PMID: 24205193 PMC: 3808353. DOI: 10.1371/journal.pone.0078309.

Neurochemical characterisation of lamina II inhibitory interneurons that express GFP in the PrP-GFP mouse.

Iwagaki N, Garzillo F, Polgar E, Riddell J, Todd A Mol Pain. 2013; 9:56.

PMID: 24176114 PMC: 4228398. DOI: 10.1186/1744-8069-9-56.

Populations of inhibitory and excitatory interneurons in lamina II of the adult rat spinal dorsal horn revealed by a combined electrophysiological and anatomical approach.

Yasaka T, Tiong S, Hughes D, Riddell J, Todd A Pain. 2010; 151(2):475-488.

PMID: 20817353 PMC: 3170912. DOI: 10.1016/j.pain.2010.08.008.

Effects of somatostatin on the responses of rostrally projecting spinal dorsal horn neurons to noxious stimuli in cats.

Jung S, Jo S, Lee S, Oh E, Kim M, Nam W Korean J Physiol Pharmacol. 2009; 12(5):253-8.

PMID: 19967064 PMC: 2788644. DOI: 10.4196/kjpp.2008.12.5.253.