A Reactive Oxygen Species-generating, Cyclooxygenase-2 Inhibiting, Cancer Stem Cell-potent Tetranuclear Copper(ii) Cluster

Overview

Journal Dalton Trans

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2017 Sep 22

PMID 28932846

Citations 15

Authors

C Lu

K Laws

A Eskandari

K Suntharalingam

Affiliations

Soon will be listed here.

Abstract

Tetranuclear copper(ii) complexes containing multiple diclofenac and Schiff base moieties, 1-4, are shown to kill bulk cancer cells and cancer stem cells (CSCs) with low micromolar potency. The most effective complex, 1, elicits its cytotoxic effect by elevating the intracellular reactive oxygen species (ROS) levels and inhibiting cyclooxygenase-2 (COX-2) expression.

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