» Articles » PMID: 28931917

Exercise Training Enhances in Vivo Clearance of Endotoxin and Attenuates Inflammatory Responses by Potentiating Kupffer Cell Phagocytosis

Overview
Journal Sci Rep
Specialty Science
Date 2017 Sep 22
PMID 28931917
Citations 15
Authors
Affiliations
Soon will be listed here.
Abstract

The failure of Kupffer cells (KCs) to remove endotoxin is an important factor in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). In this study, the effects of exercise training on KC function were studied in terms of in vivo endotoxin clearance and inflammatory responses. Mice were allocated into rest and exercise groups. KC bead phagocytic capacity and plasma steroid hormone levels were determined following exercise training. Endotoxin and inflammatory cytokine levels in plasma were determined over time following endotoxin injection. KC bead phagocytic capacity was potentiated and clearance of exogenously-injected endotoxin was increased in the exercise group. Inflammatory cytokine (TNF-α and IL-6) levels were lower in the exercise group. We found that only DHEA was increased in the plasma of the exercise group. In an in vitro experiment, the addition of DHEA to RAW264.7 cells increased bead phagocytic capacity and attenuated endotoxin-induced inflammatory responses. These results suggest that exercise training modulates in vivo endotoxin clearance and inflammatory responses in association with increased DHEA production. These exercise-induced changes in KC capacity may contribute to a slowing of disease progression in NAFLD patients.

Citing Articles

Rehabilitation Training after Spinal Cord Injury Affects Brain Structure and Function: From Mechanisms to Methods.

He L, Guo X, Zhao C, Rao J Biomedicines. 2024; 12(1).

PMID: 38255148 PMC: 10813763. DOI: 10.3390/biomedicines12010041.


Macrophage specific restoration of the Nrf2 gene in whole-body knockout mice ameliorates steatohepatitis induced by lipopolysaccharide from Porphyromonas gingivalis through enhanced hepatic clearance.

Chihara K, Okada K, Uchida F, Miura I, Komine S, Warabi E PLoS One. 2023; 18(10):e0291880.

PMID: 37862331 PMC: 10588835. DOI: 10.1371/journal.pone.0291880.


Ontogeny, functions and reprogramming of Kupffer cells upon infectious disease.

Musrati M, De Baetselier P, Movahedi K, Van Ginderachter J Front Immunol. 2023; 14:1238452.

PMID: 37691953 PMC: 10485603. DOI: 10.3389/fimmu.2023.1238452.


Physical Activity Protocols in Non-Alcoholic Fatty Liver Disease Management: A Systematic Review of Randomized Clinical Trials and Animal Models.

Barron-Cabrera E, Soria-Rodriguez R, Amador-Lara F, Martinez-Lopez E Healthcare (Basel). 2023; 11(14).

PMID: 37510432 PMC: 10379178. DOI: 10.3390/healthcare11141992.


Exercise modifies the disease-relevant gut microbial shifts in post-traumatic osteoarthritis rats.

Hao X, Zhang J, Shang X, Sun K, Zhou J, Liu J Bone Joint Res. 2022; 11(4):214-225.

PMID: 35382556 PMC: 9057523. DOI: 10.1302/2046-3758.114.BJR-2021-0192.R1.


References
1.
Kinoshita M, Uchida T, Sato A, Nakashima M, Nakashima H, Shono S . Characterization of two F4/80-positive Kupffer cell subsets by their function and phenotype in mice. J Hepatol. 2010; 53(5):903-10. DOI: 10.1016/j.jhep.2010.04.037. View

2.
Nakatani Y, Fukui H, Kitano H, Nagamoto I, Tsujimoto T, Kuriyama S . Endotoxin clearance and its relation to hepatic and renal disturbances in rats with liver cirrhosis. Liver. 2001; 21(1):64-70. DOI: 10.1034/j.1600-0676.2001.210110.x. View

3.
Sharifnia T, Antoun J, Verriere T, Suarez G, Wattacheril J, Wilson K . Hepatic TLR4 signaling in obese NAFLD. Am J Physiol Gastrointest Liver Physiol. 2015; 309(4):G270-8. PMC: 4537925. DOI: 10.1152/ajpgi.00304.2014. View

4.
Iijima H, Moriyasu F, Tsuchiya K, Suzuki S, Yoshida M, Shimizu M . Decrease in accumulation of ultrasound contrast microbubbles in non-alcoholic steatohepatitis. Hepatol Res. 2007; 37(9):722-30. DOI: 10.1111/j.1872-034X.2007.00130.x. View

5.
Yano H, Kinoshita S, Kira S . Effects of acute moderate exercise on the phagocytosis of Kupffer cells in rats. Acta Physiol Scand. 2004; 182(2):151-60. DOI: 10.1111/j.1365-201X.2004.01343.x. View