LncRNA SNHG1 Enhances Cell Proliferation, Migration, and Invasion in Cervical Cancer

Overview

Journal Biochem Cell Biol

Specialties Biochemistry
Cell Biology

Date 2017 Sep 21

PMID 28930646

Citations 75

Authors

Yang Liu

Yanling Yang

Lei Li

Yuan Liu

Peng Geng

Guilin Li

Hongjuan Song

Affiliations

Soon will be listed here.

Abstract

Objective: This study investigated the effects of lncRNA SNHG1 on the proliferation, migration, and invasiveness of cervical cancer cells.

Methods: Three pairs of cervical cancer tissue samples and their corresponding adjacent samples were analyzed using Human LncRNA Microarray V3.0 chip for differential analysis. The expression of SNHG1 in cervical cancer cell lines was verified by qRT-PCR. CCK8 assays and colony formation assays were used to study the changes in cell proliferation. Cell migration and Transwell assays were used to study changes in cell migration and invasiveness.

Results: SNHG1 was highly expressed in cervical cancer tissues and cervical cancer cell lines. SNHG1 siRNA could knock-down the expression level of SNHG1 in cervical cancer cell lines HeLa and C33-A. After knock-down of SNHG1, cell proliferation and migration as well as invasiveness in HeLa and C-33A cells decreased.

Conclusion: LncRNA SNHG1 promotes the development of cervical cancer cells.

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