A Reassessment of the Marrubium Vulgare L. Herb's Potential Role in Diabetes Mellitus Type 2: First Results Guide the Investigation Toward New Horizons

Overview

Journal Medicines (Basel)

Specialty Pharmacology

Date 2017 Sep 21

PMID 28930271

Citations 4

Authors

Javier Rodriguez Villanueva

Jorge Martin Esteban

Laura Rodriguez Villanueva

Affiliations

Soon will be listed here.

Abstract

Despite the wide variety of pharmacological activities described for the L. herb, amazingly, only one clinical trial can be found in scientific literature. It was designed for the evaluation of its antidiabetic activity. Worse, the outcomes of this trial were contradictory to what previous in vivo mice assays had concluded. Therefore, should be ruled out due to its lack of therapeutic potential in diabetes? The authors suggest a reevaluation of the clinical trial methodology to establish valid and final results.

Citing Articles

Clinical Implications of Herbal Supplements in Conventional Medical Practice: A US Perspective.

Hassen G, Belete G, Carrera K, Iriowen R, Araya H, Alemu T Cureus. 2022; 14(7):e26893.

PMID: 35978741 PMC: 9375827. DOI: 10.7759/cureus.26893.

Potential Application of Some Lamiaceae Species in the Management of Diabetes.

Etsassala N, Hussein A, Nchu F Plants (Basel). 2021; 10(2).

PMID: 33535455 PMC: 7912742. DOI: 10.3390/plants10020279.

L.: A Phytochemical and Pharmacological Overview.

Acimovic M, Jeremic K, Salaj N, Gavaric N, Kiprovski B, Sikora V Molecules. 2020; 25(12).

PMID: 32599693 PMC: 7355696. DOI: 10.3390/molecules25122898.

Does the World Need Plant Medicines?.

Adams J Medicines (Basel). 2018; 5(2).

PMID: 29690579 PMC: 6023376. DOI: 10.3390/medicines5020039.

References

El Bardai S, Lyoussi B, Wibo M, Morel N . Comparative study of the antihypertensive activity of Marrubium vulgare and of the dihydropyridine calcium antagonist amlodipine in spontaneously hypertensive rat. Clin Exp Hypertens. 2004; 26(6):465-74. DOI: 10.1081/ceh-200031818. View

Herrera-Arellano A, Aguilar-Santamaria L, Garcia-Hernandez B, Nicasio-Torres P, Tortoriello J . Clinical trial of Cecropia obtusifolia and Marrubium vulgare leaf extracts on blood glucose and serum lipids in type 2 diabetics. Phytomedicine. 2005; 11(7-8):561-6. DOI: 10.1016/j.phymed.2004.01.006. View

Rodriguez Villanueva J, Martin Esteban J, Rodriguez Villanueva L . Solving the puzzle: What is behind our forefathers' anti-inflammatory remedies?. J Intercult Ethnopharmacol. 2017; 6(1):128-143. PMC: 5289082. DOI: 10.5455/jice.20161204021732. View

Mittal V, Nanda A . Intensification of marrubiin concentration by optimization of microwave-assisted (low CO yielding) extraction process for Marrubium vulgare using central composite design and antioxidant evaluation. Pharm Biol. 2017; 55(1):1337-1347. PMC: 7012001. DOI: 10.1080/13880209.2017.1297837. View

Rodriguez Villanueva J, Martin Esteban J . An Insight into a Blockbuster Phytomedicine; Marrubium vulgare L. Herb. More of a Myth than a Reality?. Phytother Res. 2016; 30(10):1551-1558. DOI: 10.1002/ptr.5661. View

Kahkeshani N, Gharedaghi M, Hadjiakhoondi A, Sharifzadeh M, Khanavi M . Antinociceptive effect of extracts of Jacq. aerial parts. Avicenna J Phytomed. 2017; 7(1):73-79. PMC: 5329179. View

Aouni R, Attia M, Jaafoura M, Bibi-Derbel A, Haouari M . Effects of the hydro-ethanolic extract of Marrubium vulgare in female rats. Asian Pac J Trop Med. 2017; 10(2):160-164. DOI: 10.1016/j.apjtm.2017.01.010. View

Izzo A, Hoon-Kim S, Radhakrishnan R, Williamson E . A Critical Approach to Evaluating Clinical Efficacy, Adverse Events and Drug Interactions of Herbal Remedies. Phytother Res. 2016; 30(5):691-700. DOI: 10.1002/ptr.5591. View

Boudjelal A, Henchiri C, Siracusa L, Sari M, Ruberto G . Compositional analysis and in vivo anti-diabetic activity of wild Algerian Marrubium vulgare L. infusion. Fitoterapia. 2011; 83(2):286-92. DOI: 10.1016/j.fitote.2011.11.005. View

10.

Garjani A, Tila D, Hamedeyazdan S, Vaez H, Rameshrad M, Pashaii M . An investigation on cardioprotective potential of Marrubium vulgare aqueous fraction against ischaemia-reperfusion injury in isolated rat heart. Folia Morphol (Warsz). 2017; 76(3):361-371. DOI: 10.5603/FM.a2017.0011. View

11.

Ohtera A, Miyamae Y, Nakai N, Kawachi A, Kawada K, Han J . Identification of 6-octadecynoic acid from a methanol extract of Marrubium vulgare L. as a peroxisome proliferator-activated receptor γ agonist. Biochem Biophys Res Commun. 2013; 440(2):204-9. DOI: 10.1016/j.bbrc.2013.09.003. View

12.

Barkaoui M, Katiri A, Boubaker H, Msanda F . Ethnobotanical survey of medicinal plants used in the traditional treatment of diabetes in Chtouka Ait Baha and Tiznit (Western Anti-Atlas), Morocco. J Ethnopharmacol. 2017; 198:338-350. DOI: 10.1016/j.jep.2017.01.023. View

13.

El Bardai S, Hamaide M, Lyoussi B, Quetin-Leclercq J, Morel N, Wibo M . Marrubenol interacts with the phenylalkylamine binding site of the L-type calcium channel. Eur J Pharmacol. 2004; 492(2-3):269-72. DOI: 10.1016/j.ejphar.2004.04.007. View

14.

Roman Ramos R, Alarcon-Aguilar F, Flores-Saenz J . Hypoglycemic effect of plants used in Mexico as antidiabetics. Arch Med Res. 1992; 23(1):59-64. View

15.

Wolsko P, Solondz D, Phillips R, Schachter S, Eisenberg D . Lack of herbal supplement characterization in published randomized controlled trials. Am J Med. 2005; 118(10):1087-93. DOI: 10.1016/j.amjmed.2005.01.076. View