Endoscopic Ultrasound and Related Technologies for the Diagnosis and Treatment of Pancreatic Disease - Research Gaps and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop

Overview

Journal Pancreas

Specialty Gastroenterology

Date 2017 Sep 20

PMID 28926412

Citations 4

Authors

Linda S Lee

Dana K Andersen

Reiko Ashida

William R Brugge

Mimi I Canto

Kenneth J Chang

Suresh T Chari

John DeWitt

Joo Ha Hwang

Mouen A Khashab

Kang Kim

Michael J Levy

Kevin McGrath

Walter G Park

Aatur Singhi

Tyler Stevens

Christopher C Thompson

Mark D Topazian

Michael B Wallace

Sachin Wani

Irving Waxman

Dhiraj Yadav

Vikesh K Singh

Affiliations

Soon will be listed here.

Abstract

A workshop was sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases to address the research gaps and opportunities in pancreatic endoscopic ultrasound (EUS). The event occurred on July 26, 2017 in 4 sessions: (1) benign pancreatic diseases, (2) high-risk pancreatic diseases, (3) diagnostic and therapeutics, and (4) new technologies. The current state of knowledge was reviewed, with identification of numerous gaps in knowledge and research needs. Common themes included the need for large multicenter consortia of various pancreatic diseases to facilitate meaningful research of these entities; to standardize EUS features of different pancreatic disorders, the technique of sampling pancreatic lesions, and the performance of various therapeutic EUS procedures; and to identify high-risk disease early at the cellular level before macroscopic disease develops. The need for specialized tools and accessories to enable the safe and effective performance of therapeutic EUS procedures also was discussed.

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References

Affolter K, Schmidt R, Matynia A, Adler D, Factor R . Needle size has only a limited effect on outcomes in EUS-guided fine needle aspiration: a systematic review and meta-analysis. Dig Dis Sci. 2012; 58(4):1026-34. DOI: 10.1007/s10620-012-2439-2. View

Rajan E, Clain J, Levy M, Norton I, Wang K, Wiersema M . Age-related changes in the pancreas identified by EUS: a prospective evaluation. Gastrointest Endosc. 2005; 61(3):401-6. DOI: 10.1016/s0016-5107(04)02758-0. View

Conwell D, Lee L, Yadav D, Longnecker D, Miller F, Mortele K . American Pancreatic Association Practice Guidelines in Chronic Pancreatitis: evidence-based report on diagnostic guidelines. Pancreas. 2014; 43(8):1143-62. PMC: 5434978. DOI: 10.1097/MPA.0000000000000237. View

Li T, Wang Y, Khokhlova T, DAndrea S, Starr F, Chen H . Pulsed High-Intensity Focused Ultrasound Enhances Delivery of Doxorubicin in a Preclinical Model of Pancreatic Cancer. Cancer Res. 2015; 75(18):3738-46. PMC: 4629806. DOI: 10.1158/0008-5472.CAN-15-0296. View

Springer S, Wang Y, Dal Molin M, Masica D, Jiao Y, Kinde I . A combination of molecular markers and clinical features improve the classification of pancreatic cysts. Gastroenterology. 2015; 149(6):1501-10. PMC: 4782782. DOI: 10.1053/j.gastro.2015.07.041. View

DiMagno E, Regan P, Clain J, JAMES E, Buxton J . Human endoscopic ultrasonography. Gastroenterology. 1982; 83(4):824-9. View

Wyse J, Carone M, Paquin S, Usatii M, Sahai A . Randomized, double-blind, controlled trial of early endoscopic ultrasound-guided celiac plexus neurolysis to prevent pain progression in patients with newly diagnosed, painful, inoperable pancreatic cancer. J Clin Oncol. 2011; 29(26):3541-6. DOI: 10.1200/JCO.2010.32.2750. View

Puri R, Vilmann P, Saftoiu A, Skov B, Linnemann D, Hassan H . Randomized controlled trial of endoscopic ultrasound-guided fine-needle sampling with or without suction for better cytological diagnosis. Scand J Gastroenterol. 2009; 44(4):499-504. DOI: 10.1080/00365520802647392. View

Hisanaga K, Hisanaga A, Ichie Y, Nishimura K, Hibi N, Fukui Y . Transoesophageal pulsed doppler echocardiography. Lancet. 1979; 1(8106):53-4. DOI: 10.1016/s0140-6736(79)90506-3. View

10.

Catenacci D, Chapman C, Xu P, Koons A, Konda V, Siddiqui U . Acquisition of Portal Venous Circulating Tumor Cells From Patients With Pancreaticobiliary Cancers by Endoscopic Ultrasound. Gastroenterology. 2015; 149(7):1794-1803.e4. PMC: 4985007. DOI: 10.1053/j.gastro.2015.08.050. View

11.

Lee J, Kim S, Won Jun D, Han J, Jang E, Park J . Clinical implications of fatty pancreas: correlations between fatty pancreas and metabolic syndrome. World J Gastroenterol. 2009; 15(15):1869-75. PMC: 2670415. DOI: 10.3748/wjg.15.1869. View

12.

Willmann J, Bonomo L, Testa A, Rinaldi P, Rindi G, Valluru K . Ultrasound Molecular Imaging With BR55 in Patients With Breast and Ovarian Lesions: First-in-Human Results. J Clin Oncol. 2017; 35(19):2133-2140. PMC: 5493049. DOI: 10.1200/JCO.2016.70.8594. View

13.

Sepe P, Ohri A, Sanaka S, Berzin T, Sekhon S, Bennett G . A prospective evaluation of fatty pancreas by using EUS. Gastrointest Endosc. 2011; 73(5):987-93. DOI: 10.1016/j.gie.2011.01.015. View

14.

Siddiqui A, Kowalski T, Loren D, Khalid A, Soomro A, Mazhar S . Fully covered self-expanding metal stents versus lumen-apposing fully covered self-expanding metal stent versus plastic stents for endoscopic drainage of pancreatic walled-off necrosis: clinical outcomes and success. Gastrointest Endosc. 2016; 85(4):758-765. DOI: 10.1016/j.gie.2016.08.014. View

15.

Wani S, Wallace M, Cohen J, Pike I, Adler D, Kochman M . Quality indicators for EUS. Am J Gastroenterol. 2014; 110(1):102-13. DOI: 10.1038/ajg.2014.387. View

16.

Abou-Elkacem L, Bachawal S, Willmann J . Ultrasound molecular imaging: Moving toward clinical translation. Eur J Radiol. 2015; 84(9):1685-93. PMC: 4545409. DOI: 10.1016/j.ejrad.2015.03.016. View

17.

Levy M, Thompson G, Topazian M, Callstrom M, Grant C, Vella A . US-guided ethanol ablation of insulinomas: a new treatment option. Gastrointest Endosc. 2011; 75(1):200-6. DOI: 10.1016/j.gie.2011.09.019. View

18.

Thompson C, Kumar N, Slattery J, Clancy T, Ryan M, Ryou M . A standardized method for endoscopic necrosectomy improves complication and mortality rates. Pancreatology. 2016; 16(1):66-72. PMC: 4762002. DOI: 10.1016/j.pan.2015.12.001. View

19.

Trikudanathan G, Munigala S, Barlass U, Malli A, Han Y, Sekulic M . Evaluation of Rosemont criteria for non-calcific chronic pancreatitis (NCCP) based on histopathology - A retrospective study. Pancreatology. 2016; 17(1):63-69. DOI: 10.1016/j.pan.2016.10.010. View

20.

Bissolati M, Sandri M, Burtulo G, Zorzino L, Balzano G, Braga M . Portal vein-circulating tumor cells predict liver metastases in patients with resectable pancreatic cancer. Tumour Biol. 2014; 36(2):991-6. DOI: 10.1007/s13277-014-2716-0. View