Blood Flow Regulation and Oxidative Stress During Submaximal Cycling Exercise in Patients with Cystic Fibrosis

Overview

Journal J Cyst Fibros

Publisher Elsevier

Specialty Pulmonary Medicine

Date 2017 Sep 20

PMID 28923457

Citations 8

Authors

Matthew A Tucker

Breana Berry

Nichole Seigler

Gareth W Davison

John C Quindry

Dabney Eidson

Kathleen T McKie

Ryan A Harris

Affiliations

Soon will be listed here.

Abstract

Background: The impact of blood flow regulation and oxidative stress during exercise in cystic fibrosis (CF) has yet to be investigated.

Methods: A maximal graded exercise test was conducted to determine exercise capacity (VO peak) and peak workload in 14 pediatric patients with mild CF (age 14±3y, FEV 93±16 % predicted) and 14 demographically-matched controls. On a separate visit, participants performed submaximal cycling up to 60% of peak workload where brachial artery blood velocity was determined using Doppler ultrasound. Retrograde and antegrade components were further analyzed as indices of blood flow regulation.

Results: The cumulative AUC for retrograde velocity was lower in patients versus controls (1770±554 vs. 3440±522cm, P=0.038). In addition, an exaggerated oxidative stress response during exercise occurred in patients only (P=0.004).

Conclusion: These data suggest that patients with mild CF exhibit impaired blood flow regulation and an exaggerated oxidative stress response to submaximal exercise.

Citing Articles

Prevalence, risk factors and outcomes of cardiac disease in cystic fibrosis: a multinational retrospective cohort study.

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Skeletal muscle contributions to reduced fitness in cystic fibrosis youth.

Tomlinson O, Barker A, Fulford J, Wilson P, Shelley J, Oades P Front Pediatr. 2023; 11:1211547.

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The Interplay between Oxidative Stress, Exercise, and Pain in Health and Disease: Potential Role of Autonomic Regulation and Epigenetic Mechanisms.

Hendrix J, Nijs J, Ickmans K, Godderis L, Ghosh M, Polli A Antioxidants (Basel). 2020; 9(11).

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Circulating biomarkers of antioxidant status and oxidative stress in people with cystic fibrosis: A systematic review and meta-analysis.

Causer A, Shute J, Cummings M, Shepherd A, Gruet M, Costello J Redox Biol. 2020; 32:101436.

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Exercise Physiology Across the Lifespan in Cystic Fibrosis.

Shei R, Mackintosh K, Lever J, McNarry M, Krick S Front Physiol. 2019; 10:1382.

PMID: 31780953 PMC: 6856653. DOI: 10.3389/fphys.2019.01382.

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