Foxp3 is Correlated with VEGF-C Expression and Lymphangiogenesis in Cervical Cancer

Overview

Journal World J Surg Oncol

Publisher Biomed Central

Specialties General Surgery
Oncology

Date 2017 Sep 20

PMID 28923073

Citations 18

Authors

Jiabu Tang

Zheng Yang

Zhuo Wang

Zhen Li

Hongmei Li

Jinbao Yin

Min Deng

Wei Zhu

Chao Zeng

Affiliations

Soon will be listed here.

Abstract

Background: Recent observations revealed Foxp3 participated in the development of cervical cancer. Furthermore, Foxp3 has a vital function in the lymphatic metastasis of cervical cancer. However, it is unclear whether Foxp3 is correlated with lymphangiogenesis of cervical cancer.

Methods: In this experiment, expression of Foxp3 and VEGF-C was detected in 50 cervical cancer samples by immunohistochemistry. In addition, we evaluated the association between Foxp3 and VEGF-C expression and lymphangiogenesis of cervical cancer evaluated by lymphatic vessel density.

Results: These data demonstrate Foxp3 is positively correlated with VEGF-C expression. Furthermore, Foxp3 is associated with lymphangiogenesis of cervical cancer.

Conclusions: These results revealed Foxp3 play an important role in lymphangiogenesis of cervical cancer.

Trial Registration: Gunagdong Medical University, PJ2013049.

Citing Articles

FOXP3 serum concentration; a likely predictor of CIN and cervical cancer: Secondary analysis from a case control study at a clinic in South western Uganda.

Ssedyabane F, Niyonzima N, Ngonzi J, Nambi Najjuma J, Mudondo H, Okeny C Gynecol Oncol Rep. 2024; 55:101466.

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Mucosal T-cell responses to chronic viral infections: Implications for vaccine design.

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Tumor microenvironment promotes lymphatic metastasis of cervical cancer: its mechanisms and clinical implications.

Li Y, Gao X, Huang Y, Zhu X, Chen Y, Xue L Front Oncol. 2023; 13:1114042.

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The Role of FOXP3 on Tumor Metastasis and Its Interaction with Traditional Chinese Medicine.

Ma B, Miao W, Xiao J, Chen X, Xu J, Li Y Molecules. 2022; 27(19).

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Role of FoxP3-positive regulatory T-cells in regressive and progressive cervical dysplasia.

Vattai A, Kremer N, Meister S, Beyer S, Keilmann L, Hester A J Cancer Res Clin Oncol. 2021; 148(2):377-386.

PMID: 34739585 DOI: 10.1007/s00432-021-03838-6.

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