Carbon Nanotubes Gathered Onto Silica Particles Lose Their Biomimetic Properties with the Cytoskeleton Becoming Biocompatible

Overview

Journal Int J Nanomedicine

Publisher Dove Medical Press

Specialty Biotechnology

Date 2017 Sep 19

PMID 28919736

Citations 11

Authors

Elena Gonzalez-Dominguez

Nerea Iturrioz-Rodriguez

Esperanza Padin-Gonzalez

Juan Villegas

Lorena Garcia-Hevia

Moises Perez-Lorenzo

Wolfgang J Parak

Miguel A Correa-Duarte

Monica L Fanarraga

Affiliations

Soon will be listed here.

Abstract

Carbon nanotubes (CNTs) are likely to transform the therapeutic and diagnostic fields in biomedicine during the coming years. However, the fragmented vision of their side effects and toxicity in humans has proscribed their use as nanomedicines. Most studies agree that biocompatibility depends on the state of aggregation/dispersion of CNTs under physiological conditions, but conclusions are confusing so far. This study designs an experimental setup to investigate the cytotoxic effect of individualized multiwalled CNTs compared to that of identical nanotubes assembled on submicrometric structures. Our results demonstrate how CNT cytotoxicity is directly dependent on the nanotube dispersion at a given dosage. When CNTs are gathered onto silica templates, they do not interfere with cell proliferation or survival becoming highly compatible. These results support the hypothesis that CNT cytotoxicity is due to the biomimetics of these nanomaterials with the intracellular nanofilaments. These findings provide major clues for the development of innocuous CNT-containing nanodevices and nanomedicines.

Citing Articles

Biodegradable silica nanoparticles for efficient linear DNA gene delivery.

Ramos-Valle A, Kirst H, Fanarraga M Drug Deliv. 2024; 31(1):2385376.

PMID: 39101224 PMC: 11302475. DOI: 10.1080/10717544.2024.2385376.

Carbon-Based Nanomaterials as Drug Delivery Agents for Colorectal Cancer: Clinical Preface to Colorectal Cancer Citing Their Markers and Existing Theranostic Approaches.

Ma J, Wang G, Ding X, Wang F, Zhu C, Rong Y ACS Omega. 2023; 8(12):10656-10668.

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Carbon Nanotubes as Carriers in Drug Delivery for Non-Small Cell Lung Cancer, Mechanistic Analysis of Their Carcinogenic Potential, Safety Profiling and Identification of Biomarkers.

Pu Z, Wei Y, Sun Y, Wang Y, Zhu S Int J Nanomedicine. 2022; 17:6157-6180.

PMID: 36523423 PMC: 9744892. DOI: 10.2147/IJN.S384592.

Design of Polymeric and Biocompatible Delivery Systems by Dissolving Mesoporous Silica Templates.

Rodriguez-Ramos A, Marin-Caba L, Iturrioz-Rodriguez N, Padin-Gonzalez E, Garcia-Hevia L, Mena Oliveira T Int J Mol Sci. 2020; 21(24).

PMID: 33339139 PMC: 7765674. DOI: 10.3390/ijms21249573.

Microtubule cytoskeleton-disrupting activity of MWCNTs: applications in cancer treatment.

Hevia L, Fanarraga M J Nanobiotechnology. 2020; 18(1):181.

PMID: 33317574 PMC: 7734827. DOI: 10.1186/s12951-020-00742-y.

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