Axitinib-related Osteonecrosis of the Jaw

Overview

Journal Oral Surg Oral Med Oral Pathol Oral Radiol

Publisher Elsevier

Specialties Dentistry
General Surgery

Date 2017 Sep 19

PMID 28918879

Citations 11

Authors

Vinod Patel

Chris Sproat

Jerry Kwok

Nikki Tanna

Affiliations

Soon will be listed here.

Abstract

Tyrosine kinase inhibitors (TKIs) are oral chemotherapy drugs used primarily to treat leukemias, renal cell carcinomas, gastrointestinal stromal tumors, and neuroendocrine tumors. Within this group, a number of drugs have already been implicated in jaw necrosis. Axitinib (Inlyta) is a novel TKI currently licensed for the treatment of renal cell carcinoma. We report the first case, to our knowledge, of jaw necrosis solely related to this medication and review the literature surrounding TKIs and their implication in osteonecrosis of the jaw.

Citing Articles

Osteonecrosis of the jaw in patients with clear cell renal cell carcinoma treated with targeted agents: a case series and large-scale pharmacovigilance analysis.

Wang S, Zhang R, Wang S, Guo Q, Yin D, Song Y Front Pharmacol. 2024; 15:1309148.

PMID: 39534085 PMC: 11555396. DOI: 10.3389/fphar.2024.1309148.

Exploring the Impact of Novel Anti-Cancer Therapies on Jaw Osteonecrosis and Other Bones: A Comprehensive Review.

Konarski W, Pobozy T, Konarska K, Sliwczynski A, Kotela I, Krakowiak J J Clin Med. 2024; 13(7).

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Bone Metabolism Effects of Medical Therapy in Advanced Renal Cell Carcinoma.

Paragliola R, Torino F, Barnabei A, Iannantuono G, Corsello A, Locantore P Cancers (Basel). 2023; 15(2).

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Oral Side Effects in Patients with Metastatic Renal Cell Carcinoma Receiving the Antiangiogenic Agent Pazopanib-Report of Three Cases.

Papadopoulou E, Vardas E, Tziveleka S, Georgaki M, Kouri M, Katoumas K Dent J (Basel). 2022; 10(12).

PMID: 36547048 PMC: 9777138. DOI: 10.3390/dj10120232.

The impact of sex steroids on osteonecrosis of the jaw.

Kim R, Kim S, Kim H, Ku S Osteoporos Sarcopenia. 2022; 8(2):58-67.

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