Natural and Synthetic Polymers/bioceramics/bioactive Compounds-mediated Cell Signalling in Bone Tissue Engineering

Overview

Journal Int J Biol Macromol

Publisher Elsevier

Date 2017 Sep 18

PMID 28917940

Citations 46

Authors

S Harsha Rao

B Harini

R Pranav Kumar Shadamarshan

K Balagangadharan

N Selvamurugan

Affiliations

Soon will be listed here.

Abstract

Bone is a highly integrative and dynamic tissue of the human body. It is continually remodeled by bone cells such as osteoblasts, osteoclasts. When a fraction of a bone is damaged or deformed, stem cells and bone cells under the influence of several signaling pathways regulate bone regeneration at the particular locale. Effective therapies for bone defects can be met via bone tissue engineering which employs drug delivery systems with biomaterials to enhance cellular functions by acting on signaling pathways such as Wnt, BMP, TGF-β, and Notch. This review provides the current understanding of polymers/bioceramics/bioactive compounds as scaffolds in activation of signaling pathways for the formation of bone.

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