Were All Carbapenemases Created Equal? Treatment of NDM-producing Extensively Drug-resistant Enterobacteriaceae: a Case Report and Literature Review

Overview

Journal Infection

Date 2017 Sep 17

PMID 28916900

Citations 13

Authors

Vindana Chibabhai

Trusha Nana

Norma Bosman

Teena Thomas

Warren Lowman

Affiliations

Soon will be listed here.

Abstract

Purpose: There is currently a paucity of published literature focused on the treatment of infections caused by NDM-producing organisms.

Methods: We describe a case of a bacteraemia caused by an extensively drug-resistant (XDR) New Delhi metallo-β-lactamase (NDM)-producing Serratia marcescens and review the treatment options for XDR NDM-producing Enterobacteriaceae.

Results: Infections caused by New Delhi beta-lactamase (NDM)-producing Enterobacteriaceae are becoming increasingly prevalent worldwide. The presence of the enzyme results in multidrug-resistant and extensively drug-resistant phenotypes which often pose a treatment challenge. Despite this challenge, case reports and series have demonstrated good clinical outcomes with numerous treatment options in comparison to infections due to KPC-producing Enterobacteriaceae.

Conclusions: Further good-quality research focused on the treatment of NDM-producing Enterobacteriaceae is warranted.

Citing Articles

Deciphering the Efficacy of β-Lactams in the Face of Metallo-β-Lactamase-Derived Resistance in Enterobacterales: Supraphysiologic Zinc in the Broth Is the Culprit.

Abdelraouf K, Gill C, Gethers M, Tiseo G, Barnini S, Falcone M Open Forum Infect Dis. 2024; 11(5):ofae228.

PMID: 38813259 PMC: 11134298. DOI: 10.1093/ofid/ofae228.

First case of bloodstream infection caused by NDM-positive Escherichia hermannii.

Lu B, Wang B, Pan X, Liu C, Jin C, Shi Y BMC Infect Dis. 2023; 23(1):355.

PMID: 37231346 PMC: 10214694. DOI: 10.1186/s12879-023-08336-3.

Increased zinc levels facilitate phenotypic detection of ceftazidime-avibactam resistance in metallo-β-lactamase-producing Gram-negative bacteria.

Simon M, Gerlach R, Pfeifer Y, Pfennigwerth N, Gatermann S, Schroder A Front Microbiol. 2022; 13:977330.

PMID: 36483203 PMC: 9723239. DOI: 10.3389/fmicb.2022.977330.

Descriptive analysis of infections due to New Delhi metallo-β-lactamase-producing Enterobacterales in children at Red Cross War Memorial Children's Hospital.

Greybe L, Nuttall J, Brink A, Tootla H S Afr J Infect Dis. 2022; 37(1):440.

PMID: 35935170 PMC: 9350446. DOI: 10.4102/sajid.v37i1.440.

In vitro Synergistic Activities of Fosfomycin in Combination with Other Antimicrobial Agents Against Carbapenem-Resistant Harboring on the IncN2 Plasmid and a Study of the Genomic Characteristics of These Pathogens.

Kaewnirat K, Chuaychob S, Chukamnerd A, Pomwised R, Surachat K, Phoo M Infect Drug Resist. 2022; 15:1777-1791.

PMID: 35437346 PMC: 9013254. DOI: 10.2147/IDR.S357965.

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