The PI3K/Akt Pathway: a Critical Player in Intervertebral Disc Degeneration

Overview

Journal Oncotarget

Specialty Oncology

Date 2017 Sep 17

PMID 28915718

Citations 57

Authors

Zhi-Hua Ouyang

Wen-Jun Wang

Yi-Guo Yan

Bing Wang

Guo-Hua Lv

Affiliations

Soon will be listed here.

Abstract

Intervertebral disc degeneration (IDD) is thought to be the primary cause of low back pain, a severe public health problem worldwide. Current therapy for IDD aims to alleviate the symptoms and does not target the underlying pathological alternations within the disc. Activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway protects against IDD, which is attributed to increase of ECM content, prevention of cell apoptosis, facilitation of cell proliferation, induction or prevention of cell autophagy, alleviation of oxidative damage, and adaptation of hypoxic microenvironment. In the current review, we summarize recent progression on activation and negative regulation of the PI3K/Akt signaling pathway, and highlight its impact on IDD. Targeting this pathway could become an attractive therapeutic strategy for IDD in the near future.

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