Folate Metabolism Genetic Polymorphisms and Meningioma and Glioma Susceptibility in Adults

Overview

Journal Oncotarget

Specialty Oncology

Date 2017 Sep 17

PMID 28915669

Citations 3

Authors

Dongming Chen

Jun Dong

Ying Huang

Feng Gao

Xiaopeng Yang

Xianglun Gong

Xiaochen Lv

Chenghao Chu

Yonggang Wu

Yong Zheng

Affiliations

Soon will be listed here.

Abstract

Polymorphic variants of genes involved in folate metabolism are implicated in the susceptibility to meningioma and glioma, but the results from published articles are controversial and inconclusive. Therefore, we performed this meta-analysis including all studies available to evaluate the relationship between folate metabolism genetic polymorphisms and the susceptibility to meningioma and glioma in adults. We searched the literature in PubMed, EMBASE and Cochrane Central Library for relevant articles published up to August 2016. The odds ratios (ORs) and the corresponding 95% confidence intervals (95%Cls) were used to evaluate the associations of two folate metabolism genetic variants MTRR A66G (rs1801394) and MTHFR A1298C (rs1801131) with the risk of meningioma and glioma in adults. We found significant association of MTHFR A1298C (rs1801131) variant genotypes with increased incidence of meningioma and glioma in this study population (CA vs. AA: OR=1.22, P<0.001; CA+CC vs. AA: OR=1.18, P=0.002). Moreover, we found that MTRR A66G (rs1801394) variant genotypes was associated with increased risk of meningioma and glioma (G vs. A: OR=1.11, P=0.020; GG vs. AA+AG: OR=1.17, P=0.043; GG vs. AA: OR=1.22, P=0.023). In conclusion, our meta-analysis suggests that two folate metabolism genetic variants MTRR A66G (rs1801394) and MTHFR A1298C (rs1801131) contribute to genetic susceptibility to meningioma and glioma in adults.

Citing Articles

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Genetic variants in the folate metabolic pathway genes predict cutaneous melanoma-specific survival.

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The C677T Polymorphism of the Methylenetetrahydrofolate Reductase Gene and Susceptibility to Late-onset Alzheimer's Disease.

Yi J, Xiao L, Zhou S, Zhang W, Liu B Open Med (Wars). 2019; 14:32-40.

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