Baicalein Inhibits Pancreatic Cancer Cell Proliferation and Invasion Via Suppression of NEDD9 Expression and Its Downstream Akt and ERK Signaling Pathways

Overview

Journal Oncotarget

Specialty Oncology

Date 2017 Sep 17

PMID 28915595

Citations 18

Authors

Rong-Tao Zhou

Mei He

Ze Yu

Yang Liang

Yuzhe Nie

Sheng Tai

Chun-Bo Teng

Affiliations

Soon will be listed here.

Abstract

Baicalein, a flavone ingredient of Georgi, is a promising anti-cancer agent. However, its potential anti-pancreatic cancer effects and the underlying mechanisms are still unclear. In this study, we showed that Baicalein not only induced apoptosis, but also suppressed proliferation, migration and invasion of two pancreatic cancer cell lines BxPC-3 and PANC-1 in a dose- and time-dependent manner. Notably, Baicalein exhibited low toxicity to normal human liver or kidney cells. We further discovered that Baicalein suppressed BxPC-3 and PANC-1 cell proliferation and invasion through targeting the expression of NEDD9, a Cas scaffolding protein, to decrease Akt and ERK activities. Especially, Baicalein decreased Akt phosphorylation at T-308 via lowering NEDD9-dependent PDK1 expression. Overexpression of NEDD9 effectively rescued proliferation and invasion of BxPC-3 and PANC-1 cells dampened by Baicalein. Taken together, our findings suggest that Baicalein is a potent remedy applied to pancreatic cancer treatment in the future.

Citing Articles

Baicalein, a natural flavonoid in gastrointestinal cancers treatment: recent trends and future perspectives.

Sharma P, Pal D, Gill A, Gupta M, Goyal S, Bansal P Med Oncol. 2024; 42(1):35.

PMID: 39718726 DOI: 10.1007/s12032-024-02587-z.

and its flavonoids in the treatment of digestive system tumors.

Zhao K, Zhang J, Zhou L, Sun Z Front Pharmacol. 2024; 15:1483785.

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Therapeutic potential of flavonoids from traditional Chinese medicine in pancreatic cancer treatment.

Wan Q, Ren Q, Qiao S, Lyu A, He X, Li F Front Nutr. 2024; 11:1477140.

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The Prognostic Significance of NEDD9 Expression in Human Cancers: A Systematic Review, Meta-Analysis, and Omics Exploration.

Yasin J, Odat R, Qtaishat F, Tamimi M, Alsufi M, Younis O Technol Cancer Res Treat. 2024; 23:15330338241297597.

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The Inhibition Mechanism of Pancreatic Ductal Adenocarcinoma via LXR Receptors: A Multifaceted Approach Integrating Molecular Docking, Molecular Dynamics and Post-MD Inter-Molecular Contact Analysis.

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