Clinical High Risk for Psychosis in Children and Adolescents: a Systematic Review

Overview

Journal Eur Child Adolesc Psychiatry

Specialties Pediatrics
Psychiatry

Date 2017 Sep 16

PMID 28914382

Citations 24

Authors

Jordina Tor

Montserrat Dolz

Anna Sintes

Daniel Munoz

Marta Pardo

Elena de la Serna

Olga Puig

Gisela Sugranyes

Inmaculada Baeza

Affiliations

Soon will be listed here.

Abstract

The concept of being at risk for psychosis has been introduced both for adults and children and adolescents, but fewer studies have been conducted in the latter population. The aim of this study is to systematically review the articles associated with clinical description, interventions, outcome and other areas in children and adolescents at risk for psychosis. We searched in MEDLINE/PubMed and PsycINFO databases for articles published up to 30/06/16. Reviewed articles were prospective studies; written in English; original articles with Clinical High Risk (CHR) for psychosis samples; and mean age of samples younger than 18 years. From 103 studies initially selected, 48 met inclusion criteria and were systematically reviewed. Studies show that CHR children and adolescents present several clinical characteristics at baseline, with most attenuated positive-symptom inclusion criteria observed, reporting mostly perceptual abnormalities and suspiciousness, and presenting comorbid conditions such as depressive and anxiety disorders. CHR children and adolescents show lower general intelligence and no structural brain changes compared with controls. Original articles reviewed show rates of conversion to psychosis between 17 and 20% at 1 year follow-up and between 7 and 21% at 2 years. While 36% of patients recovered from their CHR status at 6-year follow-up, 40% still met CHR criteria. Studies in children and adolescents with CHR were conducted with different methodologies, assessments tools and small samples. It is important to conduct studies on psychopharmacological and psychological treatment, as well as replication of the few studies found.

Citing Articles

The influence of complex psychiatric comorbidities on treatment for clinical high-risk for psychosis: A preliminary study.

Moe A, Cowan H, Manges M, Wastler H, Hamilton S, Kilicoglu M Early Interv Psychiatry. 2024; 18(10):888-893.

PMID: 38986532 PMC: 11464193. DOI: 10.1111/eip.13590.

Clinical and neurodevelopmental predictors of psychotic disorders in children and adolescents at clinical high risk for psychosis: the CAPRIS study.

Dolz M, Tor J, Puig O, de la Serna E, Munoz-Samons D, Pardo M Eur Child Adolesc Psychiatry. 2024; 33(11):3925-3935.

PMID: 38642116 DOI: 10.1007/s00787-024-02436-4.

Heterogeneity of clinical symptomatology in pediatric patients at clinical high risk for psychosis.

Rintell L, Carroll D, Wales M, Gonzalez-Heydrich J, DAngelo E BMC Res Notes. 2024; 17(1):88.

PMID: 38532408 PMC: 10964501. DOI: 10.1186/s13104-024-06742-7.

The specificity of the auditory P300 responses and its association with clinical outcomes in youth with psychosis risk syndrome.

Hou Y, Qiu G, Xia H, He T, Liu X, Chen A Int J Clin Health Psychol. 2024; 24(1):100437.

PMID: 38292829 PMC: 10825643. DOI: 10.1016/j.ijchp.2024.100437.

Value of P300 amplitude in the diagnosis of untreated first-episode schizophrenia and psychosis risk syndrome in children and adolescents.

Zhang Y, Yang T, He Y, Meng F, Zhang K, Jin X BMC Psychiatry. 2023; 23(1):743.

PMID: 37828471 PMC: 10571359. DOI: 10.1186/s12888-023-05218-5.

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