Long Term Changes in Muscles Around the Knee Joint After ACL Resection in Rats: Comparisons of ACL-Resected, Contralateral and Normal Limb

Overview

Journal J Sports Sci Med

Specialty Orthopedics

Date 2017 Sep 16

PMID 28912662

Citations 1

Authors

Mahiro Ohno

Hiroto Fujiya

Katsumasa Goto

Mitsutoshi Kurosaka

Yuji Ogura

Kanaka Yatabe

Takaaki Kudo

Hajime Kobayashi

Hisateru Niki

Haruki Musha

Affiliations

Soon will be listed here.

Abstract

The purpose of this study was to investigate the long-term effects of anterior cruciate ligament (ACL) resection on the morphological and contractile characteristics of rectus femoris (RF) and semimembranosus (SM) muscles in both injured and contralateral hindlimbs in rats. Wistar male rats (8-week old) were used. No ACL-resection-associated changes in the mass of both muscles were observed 1 week after ACL resection. On the other hand, ACL-resection-associated reduction on mean fiber cross-sectional area (fiber CSA) in RF muscle lasted 48 weeks after ACL resection. Furthermore, ACL-resection associated increase in fiber composition of type I fiber in RF muscle in contralateral limbs. In addition, long-term effects of ACL resection were observed in both ACL-resected and contralateral limbs. Evidences from this study suggested that ACL resection may cause to change in the morphological (fiber CSA) and contractile (distribution of fiber types) properties of skeletal muscles around the knee joint in not only injured but also contralateral limb. Rehabilitation for quantitative and qualitative muscle changes by ACL resection may be required a special care for a long-term period.

Citing Articles

The temporal and spatial effects of reconstructive surgery on the atrophy of hindlimb muscles in anterior cruciate ligament transected rats.

Kaneguchi A, Ozawa J, Minamimoto K, Yamaoka K Physiol Res. 2022; 72(1):99-109.

PMID: 36545871 PMC: 10069818. DOI: 10.33549/physiolres.934909.

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