Comparison of the Perioperative and Postoperative Effects of Levobupivacaine and of Levobupivacaine + Adrenaline in Pediatric Tonsillectomy: A Double-Blind Randomized Study

Overview

Journal Pain Res Manag

Date 2017 Sep 16

PMID 28912639

Citations 3

Authors

Faruk Cicekci

Cigdem Sizer

Sait Selcuk Atici

Sule Arican

Adnan Karaibrahimoglu

Inci Kara

Affiliations

Soon will be listed here.

Abstract

Objectives: We aimed to assess the effects of levobupivacaine and of levobupivacaine + adrenaline administered during pediatric tonsillectomy on the postoperative period.

Methods: A total of 90 patients between the ages of five and twelve were divided randomly into two groups before tonsillectomy: levobupivacaine only (0.5%) 0.4 mg·kg or levobupivacaine (0.5%) 0.4 mg·kg + adrenaline (1 : 200.000) administered by means of peritonsillar infiltration. Primary outcomes were postoperative pain scores recorded at various intervals until 24 hours postoperatively. Secondary outcomes included postoperative nausea and vomiting (PONV), time to first oral intake, time to the first administration of analgesics and total consumption of analgesics, and the amount of bleeding for all children.

Results: In both groups, patients had the same postoperative pain scores and PONV rates, and equal amounts of analgesics were consumed up to 24 hours postoperatively. The two groups also had the same time until first oral intake, recovery time and time to the first analgesic request, and amount of bleeding.

Conclusions: Perioperative levobupivacaine infiltration on its own is a valid alternative to the combination of levobupivacaine + adrenaline for perioperative and postoperative effectiveness in pediatric tonsillectomy. This trial is registered with Australian New Zealand Clinical Trial Registry ACTRN: ACTRN12617001167358.

Citing Articles

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Mozari S, Kalateh M, Yousefi Moghadam M, Shourideh Yazdi M, Mahmoodi R, Foji S Indian J Otolaryngol Head Neck Surg. 2025; 77(1):385-391.

PMID: 40071008 PMC: 11890885. DOI: 10.1007/s12070-024-05196-4.

A scoping review of randomized clinical trials for pain management in pediatric tonsillectomy and adenotonsillectomy.

Shih M, Long B, Pecha P, White D, Liu Y, Brennan E World J Otorhinolaryngol Head Neck Surg. 2023; 9(1):9-26.

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Critical review on the efficacy and safety of levobupivacaine peritonsillar infiltration.

Alotaibi A, Carpenter D, Asdaq S Saudi J Biol Sci. 2022; 29(4):2056-2062.

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Peritonsillar dexamethasone-bupivacaine vs. bupivacaine infiltration for post-tonsillectomy pain relief in children: a randomized, double-blind, controlled study.

Kilinc L, Turk B, Turk H, Cinar S, Turgut S, Islamoglu S Eur Arch Otorhinolaryngol. 2019; 276(7):2081-2089.

PMID: 31115688 DOI: 10.1007/s00405-019-05472-y.

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