Probiotics As a Preventive Strategy for Surgical Infection in Colorectal Cancer Patients: a Systematic Review and Meta-analysis of Randomized Trials

Overview

Journal Transl Gastroenterol Hepatol

Publisher AME Publishing Company

Specialty Gastroenterology

Date 2017 Sep 15

PMID 28905008

Citations 11

Authors

Priscilla Regia de Andrade Calaca

Raquel Pedrosa Bezerra

Wendell Wagner Campos Albuquerque

Ana Lucia Figueiredo Porto

Maria Taciana Holanda Cavalcanti

Affiliations

Soon will be listed here.

Abstract

Background: Infection following abdominal surgery remains a major factor in morbidity among colorectal cancer (CRC) patients. Probiotic therapy has been suggested to improve the clinical and laboratory outcome of patients undergoing gastrointestinal surgery. The aim of this study was to investigate the efficacy of probiotic lactic acid bacteria in patients with CRC in the pre- and postoperative phases.

Methods: Systematic database searches identified 1,080 related articles. However, only seven articles were selected according to the eligibility criteria for qualitative and quantitative evaluation.

Results: Most of the reviewed articles presented satisfactory results related to the prevention of surgical inflammation in patients undergoing resection of CRC when using strains of Lactobacillus genus, predominantly.

Conclusions: Probiotics are suggested to prevent surgical inflammation of CRC, at the same time that the combination of particular microorganisms administered is beneficial to the treatment and surgical recovery.

Citing Articles

Preventive effect of probiotics on infections following colorectal cancer surgery: An umbrella meta-analysis.

Han Y, Wang Y, Guan M World J Gastrointest Surg. 2024; 16(11):3546-3558.

PMID: 39649207 PMC: 11622088. DOI: 10.4240/wjgs.v16.i11.3546.

Probiotics/Synbiotics to Reduce Infectious Complications after Colorectal Surgery: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.

Veziant J, Bonnet M, Occean B, Dziri C, Pereira B, Slim K Nutrients. 2022; 14(15).

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Cancer-Associated Microbiota: From Mechanisms of Disease Causation to Microbiota-Centric Anti-Cancer Approaches.

Dey P, Ray Chaudhuri S Biology (Basel). 2022; 11(5).

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Analysis of abnormal intestinal flora on risk of intestinal cancer and effect of heparin on formation of bacterial biofilm.

Chen Q, Xu L, Wu T, Li J, Hua L Bioengineered. 2021; 13(1):894-904.

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Gastrointestinal cancers: the role of microbiota in carcinogenesis and the role of probiotics and microbiota in anti-cancer therapy efficacy.

Kazmierczak-Siedlecka K, Ruszkowski J, Skonieczna-Zydecka K, Jedrzejczak J, Folwarski M, Makarewicz W Cent Eur J Immunol. 2021; 45(4):476-487.

PMID: 33658894 PMC: 7882408. DOI: 10.5114/ceji.2020.103353.

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