Progress and Challenges Towards Point-of-Care Diagnostic Development for Dengue

Overview

Journal J Clin Microbiol

Specialty Microbiology

Date 2017 Sep 15

PMID 28904181

Citations 30

Authors

Junxiong Pang

Po Ying Chia

David C Lye

Yee Sin Leo

Affiliations

Soon will be listed here.

Abstract

Dengue detection strategies involve viral RNA, antigen, and/or antibody detection. Each strategy has its advantages and disadvantages. Optimal, user-friendly, rapid diagnostic tests based on immunochromatographic assays are pragmatic point-of-care tests (POCTs) in regions where dengue is endemic where there are limited laboratory capabilities and optimal storage conditions. Increasingly, there is a greater public health significance for a multiplexing assay that differentiates dengue from Zika or pathogens with similar clinical presentations. Although there have been many assay/platform developments toward POCTs, independent validation and implementation remain very limited. This review highlights the current key progress and challenges toward the development of a dengue POCT.

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