Prognostic Value of MicroRNAs in Gastric Cancer: a Meta-analysis

Overview

Journal Oncotarget

Specialty Oncology

Date 2017 Sep 15

PMID 28903436

Citations 22

Authors

Yue Zhang

Dong-Hui Guan

Rong-Xiu Bi

Jin Xie

Chuan-Hua Yang

Yue-Hua Jiang

Affiliations

Soon will be listed here.

Abstract

Background: Previous articles have reported that expression levels of microRNAs (miRNAs) are associated with survival time of patients with gastric cancer (GC). A systematic review and meta-analysis was performed to study the outcome of it.

Design: Meta-analysis.

Methods: English studies estimating expression levels of miRNAs with any of survival curves in GC were identified up till March 19, 2017 through performing online searches in PubMed, EMBASE, Web of Science and Cochrane Database of Systematic Reviews by two authors independently. The pooled hazard ratios (HR) with 95% confidence intervals (CI) were used to estimate the correlation between miRNA expression and overall survival (OS).

Results: Sixty-nine relevant articles about 26 miRNAs with 6148 patients were ultimately included. GC patients with high expression of miR-20b (HR=2.38, 95%CI=1.16-4.87), 21 (HR=1.77, 95%CI=1.01-3.08), 106b (HR=1.84, 95%CI=1.15-2.94), 196a (HR=2.66, 95%CI=1.94-3.63), 196b (HR=1.67, 95%CI=1.38-2.02), 214 (HR=1.84, 95%CI=1.27-2.67) or low expression of miR-125a (HR=2.06, 95%CI=1.26-3.37), 137 (HR=3.21, 95%CI=1.68-6.13), 141 (HR=2.47, 95%CI=1.34-4.56), 145 (HR=1.62, 95%CI=1.07-2.46), 146a (HR=2.60, 95%CI=1.63-4.13), 206 (HR=2.85, 95%CI=1.73-4.70), 218 (HR=2.61, 95%CI=1.74-3.92), 451 (HR=1.73, 95%CI=1.19-2.52), 486-5p (HR=2.45, 95%CI=1.65-3.65), 506 (HR=2.07, 95%CI=1.33-3.23) have significantly poor OS (P<0.05).

Conclusions: In summary, miR-20b, 21, 106b, 125a, 137, 141, 145, 146a, 196a, 196b, 206, 214, 218, 451, 486-5p and 506 demonstrate significantly prognostic value. Among them, miR-20b, 125a, 137, 141, 146a, 196a, 206, 218, 486-5p and 506 are strong biomarkers of prognosis in GC.

Citing Articles

Diagnostic and Prognostic Values of miRNAs in High-Grade Gliomas: A Systematic Review.

Aman R, Pratama M, Satriawan R, Ardiansyah I, Suanjaya I F1000Res. 2025; 13:796.

PMID: 39959433 PMC: 11826073. DOI: 10.12688/f1000research.151350.2.

Prediction of novel biomarkers for gastric intestinal metaplasia and gastric adenocarcinoma using bioinformatics analysis.

Eskandarion M, Eskandarieh S, Shakoori Farahani A, Mahmoodzadeh H, Shahi F, Oghabian M Heliyon. 2024; 10(9):e30253.

PMID: 38737262 PMC: 11088262. DOI: 10.1016/j.heliyon.2024.e30253.

miR-122-IGF-1R signaling allied through the dysregulated lncRNA expression in gastric carcinoma.

Kadry M Toxicol Rep. 2024; 12:338-344.

PMID: 38544957 PMC: 10965482. DOI: 10.1016/j.toxrep.2024.03.005.

Non-coding RNAs and gastrointestinal cancers prognosis: an umbrella review of systematic reviews and meta-analyses of observational studies.

Zha B, Luo Y, Kamili M, Zha X Front Oncol. 2023; 13:1193665.

PMID: 37546412 PMC: 10399243. DOI: 10.3389/fonc.2023.1193665.

Prognostic value of microRNA-125a/b family in patients with gastric cancer: a meta-analysis.

Amiri-Dashatan N, Koushki M, Naghi-Zadeh M, Razzaghi M, Mohaghegh Shalmani H Gastroenterol Hepatol Bed Bench. 2022; 14(Suppl1):S1-S9.

PMID: 35154597 PMC: 8817754.

References

Hong X, Xu Y, Qiu X, Zhu Y, Feng X, Ding Z . MiR-448 promotes glycolytic metabolism of gastric cancer by downregulating KDM2B. Oncotarget. 2016; 7(16):22092-102. PMC: 5008346. DOI: 10.18632/oncotarget.8020. View

Fan D, Ren B, Yang X, Liu J, Zhang Z . Upregulation of miR-501-5p activates the wnt/β-catenin signaling pathway and enhances stem cell-like phenotype in gastric cancer. J Exp Clin Cancer Res. 2016; 35(1):177. PMC: 5111270. DOI: 10.1186/s13046-016-0432-x. View

Zhang Y, Li C, Ma L, Ding M, Zhang B . MicroRNA-224 aggrevates tumor growth and progression by targeting mTOR in gastric cancer. Int J Oncol. 2016; 49(3):1068-80. DOI: 10.3892/ijo.2016.3581. View

Krol J, Loedige I, Filipowicz W . The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet. 2010; 11(9):597-610. DOI: 10.1038/nrg2843. View

Lu Y, Hu J, Sun W, Duan X, Chen X . Prognostic value of miR-141 downregulation in gastric cancer. Genet Mol Res. 2015; 14(4):17305-11. DOI: 10.4238/2015.December.16.31. View

Liu H, Wang Y, Xing A, Shi D, Zhang H, Guo X . Prognostic Value of microRNA Signature in Patients with Gastric Cancers. Sci Rep. 2017; 7:42806. PMC: 5311868. DOI: 10.1038/srep42806. View

Huang D, Wang H, Liu R, Li H, Ge S, Bai M . miRNA27a is a biomarker for predicting chemosensitivity and prognosis in metastatic or recurrent gastric cancer. J Cell Biochem. 2013; 115(3):549-56. DOI: 10.1002/jcb.24689. View

Zhang E, Kong R, Yin D, You L, Sun M, Han L . Long noncoding RNA ANRIL indicates a poor prognosis of gastric cancer and promotes tumor growth by epigenetically silencing of miR-99a/miR-449a. Oncotarget. 2014; 5(8):2276-92. PMC: 4039162. DOI: 10.18632/oncotarget.1902. View

Naito Y, Sakamoto N, Oue N, Yashiro M, Sentani K, Yanagihara K . MicroRNA-143 regulates collagen type III expression in stromal fibroblasts of scirrhous type gastric cancer. Cancer Sci. 2013; 105(2):228-35. PMC: 4317817. DOI: 10.1111/cas.12329. View

10.

Zhang X, Yan Z, Zhang J, Gong L, Li W, Cui J . Combination of hsa-miR-375 and hsa-miR-142-5p as a predictor for recurrence risk in gastric cancer patients following surgical resection. Ann Oncol. 2011; 22(10):2257-66. DOI: 10.1093/annonc/mdq758. View

11.

Hirata K, Suzuki H, Imaeda H, Matsuzaki J, Tsugawa H, Nagano O . CD44 variant 9 expression in primary early gastric cancer as a predictive marker for recurrence. Br J Cancer. 2013; 109(2):379-86. PMC: 3721391. DOI: 10.1038/bjc.2013.314. View

12.

Li B, Zuo Q, Zhao Y, Xiao B, Zhuang Y, Mao X . MicroRNA-25 promotes gastric cancer migration, invasion and proliferation by directly targeting transducer of ERBB2, 1 and correlates with poor survival. Oncogene. 2014; 34(20):2556-65. DOI: 10.1038/onc.2014.214. View

13.

Wang Y, Shi D, Chen X, Gao C, Gao P . Clinicopathological significance of microRNA-214 in gastric cancer and its effect on cell biological behaviour. PLoS One. 2014; 9(3):e91307. PMC: 3948864. DOI: 10.1371/journal.pone.0091307. View

14.

Tierney J, Stewart L, Ghersi D, Burdett S, Sydes M . Practical methods for incorporating summary time-to-event data into meta-analysis. Trials. 2007; 8:16. PMC: 1920534. DOI: 10.1186/1745-6215-8-16. View

15.

Brenner B, Hoshen M, Purim O, David M, Ashkenazi K, Marshak G . MicroRNAs as a potential prognostic factor in gastric cancer. World J Gastroenterol. 2011; 17(35):3976-85. PMC: 3199555. DOI: 10.3748/wjg.v17.i35.3976. View

16.

Deng J, Lei W, Xiang X, Zhang L, Yu F, Chen J . MicroRNA-506 inhibits gastric cancer proliferation and invasion by directly targeting Yap1. Tumour Biol. 2015; 36(9):6823-31. DOI: 10.1007/s13277-015-3364-8. View

17.

Wang M, Gu H, Wang S, Qian H, Zhu W, Zhang L . Circulating miR-17-5p and miR-20a: molecular markers for gastric cancer. Mol Med Rep. 2012; 5(6):1514-20. DOI: 10.3892/mmr.2012.828. View

18.

Chen L, Lu M, Zhang D, Hao N, Fan Y, Wu Y . miR-1207-5p and miR-1266 suppress gastric cancer growth and invasion by targeting telomerase reverse transcriptase. Cell Death Dis. 2014; 5:e1034. PMC: 4040688. DOI: 10.1038/cddis.2013.553. View

19.

Yang T, Yang X, Wang X, Wang Y, Zhou B, Song Z . MiR-214 regulate gastric cancer cell proliferation, migration and invasion by targeting PTEN. Cancer Cell Int. 2013; 13(1):68. PMC: 3716801. DOI: 10.1186/1475-2867-13-68. View

20.

Li Y, Wen L, Wang Y, Zhou T, Ma N, Hou Z . MicroRNA-520c enhances cell proliferation, migration, and invasion by suppressing IRF2 in gastric cancer. FEBS Open Bio. 2017; 6(12):1257-1266. PMC: 5302056. DOI: 10.1002/2211-5463.12142. View