The Role of Monocyte Percentage in Osteoporosis in Male Rheumatic Diseases

Overview

Journal Am J Mens Health

Specialties Health Services
Public Health

Date 2017 Sep 14

PMID 28901203

Citations 3

Authors

Yu-Jih Su

Chao Tung Chen

Nai-Wen Tsai

Chih-Cheng Huang

Hung-Chen Wang

Chia-Te Kung

Wei-Che Lin

Ben-Chung Cheng

Chih-Min Su

Sheng-Yuan Hsiao

Cheng-Hsien Lu

Affiliations

Soon will be listed here.

Abstract

Osteoporosis is easily overlooked in male patients, especially in the field of rheumatic diseases mostly prevalent with female patients, and its link to pathogenesis is still lacking. Attenuated monocyte apoptosis from a transcriptome-wide expression study illustrates the role of monocytes in osteoporosis. This study tested the hypothesis that the monocyte percentage among leukocytes could be a biomarker of osteoporosis in rheumatic diseases. Eighty-seven males with rheumatic diseases were evaluated in rheumatology outpatient clinics for bone mineral density (BMD) and surrogate markers, such as routine peripheral blood parameters and autoantibodies. From the total number of 87 patients included in this study, only 15 met the criteria for diagnosis of osteoporosis. Both age and monocyte percentage remained independently associated with the presence of osteoporosis. Steroid dose (equivalent prednisolone dose) was negatively associated with BMD of the hip area and platelet counts were negatively associated with BMD and T score of the spine area. Besides age, monocyte percentage meets the major requirements for osteoporosis in male rheumatic diseases. A higher monocyte percentage in male rheumatic disease patients, aged over 50 years in this study, and BMD study should be considered in order to reduce the risk of osteoporosis-related fractures.

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