» Articles » PMID: 28895962

How Functional Groups Influence the ROS Generation and Cytotoxicity of Graphene Quantum Dots

Overview
Specialty Chemistry
Date 2017 Sep 13
PMID 28895962
Citations 21
Authors
Affiliations
Soon will be listed here.
Abstract

Herein we selectively deactivate the ketonic carbonyl, carboxylic, or hydroxyl groups on GQDs and compare the ROS generation ability of different GQD derivatives. The results indicate that the ROS generation ability of GQDs is closely related to the ketonic carbonyl groups. Removal of the oxygen functional groups on GQDs can increase the photostability and lower the photoinduced cytotoxicity.

Citing Articles

Advancing Cancer Therapy with Quantum Dots and Other Nanostructures: A Review of Drug Delivery Innovations, Applications, and Challenges.

Pareek A, Kumar D, Pareek A, Gupta M Cancers (Basel). 2025; 17(5).

PMID: 40075725 PMC: 11898779. DOI: 10.3390/cancers17050878.


High Carbonyl Graphene Oxide Suppresses Colorectal Cancer Cell Proliferation and Migration by Inducing Ferroptosis via the System Xc-/GSH/GPX4 Axis.

Zhou X, Zhang Q, Zhu H, Ouyang G, Wang X, Cai Y Pharmaceutics. 2025; 16(12.

PMID: 39771583 PMC: 11678421. DOI: 10.3390/pharmaceutics16121605.


Synthesis of nanohybrid consisting of taurine derived carbon dots and nanoceria for anticancer applications.

Das J, Singh T, Lalruatsangi R, Sil P Toxicol Rep. 2024; 13:101794.

PMID: 39554612 PMC: 11568780. DOI: 10.1016/j.toxrep.2024.101794.


Graphene Quantum Dots from Natural Carbon Sources for Drug and Gene Delivery in Cancer Treatment.

Osorio H, Castillo-Solis F, Barragan S, Rodriguez-Polit C, Gonzalez-Pastor R Int J Mol Sci. 2024; 25(19).

PMID: 39408866 PMC: 11476599. DOI: 10.3390/ijms251910539.


Applicability of Quantum Dots in Breast Cancer Diagnostic and Therapeutic Modalities-A State-of-the-Art Review.

Kunachowicz D, Klosowska K, Sobczak N, Kepinska M Nanomaterials (Basel). 2024; 14(17).

PMID: 39269086 PMC: 11396817. DOI: 10.3390/nano14171424.