Lectins: an Effective Tool for Screening of Potential Cancer Biomarkers

Overview

Journal PeerJ

Specialties Biology
Environmental Health
General Medicine

Date 2017 Sep 13

PMID 28894650

Citations 42

Authors

Onn Haji Hashim

Jaime Jacqueline Jayapalan

Cheng-Siang Lee

Affiliations

Soon will be listed here.

Abstract

In recent years, the use of lectins for screening of potential biomarkers has gained increased importance in cancer research, given the development in glycobiology that highlights altered structural changes of glycans in cancer associated processes. Lectins, having the properties of recognizing specific carbohydrate moieties of glycoconjugates, have become an effective tool for detection of new cancer biomarkers in complex bodily fluids and tissues. The specificity of lectins provides an added advantage of selecting peptides that are differently glycosylated and aberrantly expressed in cancer patients, many of which are not possibly detected using conventional methods because of their low abundance in bodily fluids. When coupled with mass spectrometry, research utilizing lectins, which are mainly from plants and fungi, has led to identification of numerous potential cancer biomarkers that may be used in the future. This article reviews lectin-based methods that are commonly adopted in cancer biomarker discovery research.

Citing Articles

Surface plasmon resonance microscopy identifies glycan heterogeneity in pancreatic cancer cells that influences mucin-4 binding interactions.

Aguilar Diaz de Leon J, Thirumurty M, Ly N PLoS One. 2024; 19(5):e0304154.

PMID: 38776309 PMC: 11111020. DOI: 10.1371/journal.pone.0304154.

Medical Relevance, State-of-the-Art and Perspectives of "Sweet Metacode" in Liquid Biopsy Approaches.

Pinkeova A, Kosutova N, Jane E, Lorencova L, Bertokova A, Bertok T Diagnostics (Basel). 2024; 14(7).

PMID: 38611626 PMC: 11011756. DOI: 10.3390/diagnostics14070713.

Optimization of Affinity Chromatography Based on Sepharose 4B- chitin for Rapid Purification of Agglutinin.

Heydari M, Hosseinzadeh Colagar A, Sabour D Iran J Biotechnol. 2024; 21(3):e3364.

PMID: 38344698 PMC: 10858356. DOI: 10.30498/ijb.2023.339309.3364.

A Review of the Leishmanicidal Properties of Lectins.

Grangeiro Y, Santos A, Barbosa F, Roma R, Souza R, Silva C Curr Protein Pept Sci. 2024; 25(6):443-453.

PMID: 38284715 DOI: 10.2174/0113892037275751231221053730.

Structural Analysis and Characterization of an Antiproliferative Lectin from Seeds.

Lossio C, Osterne V, Pinto-Junior V, Chen S, Oliveira M, Verduijn J Int J Mol Sci. 2023; 24(21).

PMID: 37958949 PMC: 10649158. DOI: 10.3390/ijms242115966.

References

Thomas D, Fourkala E, Apostolidou S, Gunu R, Ryan A, Jacobs I . Evaluation of serum CEA, CYFRA21-1 and CA125 for the early detection of colorectal cancer using longitudinal preclinical samples. Br J Cancer. 2015; 113(2):268-74. PMC: 4506388. DOI: 10.1038/bjc.2015.202. View

. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther. 2001; 69(3):89-95. DOI: 10.1067/mcp.2001.113989. View

dos-Santos P, Zanetti J, Vieira-de-Mello G, Rego M, Ribeiro-Silva A A, Beltrao E . Lectin histochemistry reveals SNA as a prognostic carbohydrate-dependent probe for invasive ductal carcinoma of the breast: a clinicopathological and immunohistochemical auxiliary tool. Int J Clin Exp Pathol. 2014; 7(5):2337-49. PMC: 4069892. View

Redondo M, Alvarez-Pellitero P . The effect of lectins on the attachment and invasion of Enteromyxum scophthalmi (Myxozoa) in turbot (Psetta maxima L.) intestinal epithelium in vitro. Exp Parasitol. 2010; 126(4):577-81. DOI: 10.1016/j.exppara.2010.06.008. View

Hashim O, Ng C, Gendeh S, Nik Jaafar M . IgA binding lectins isolated from distinct Artocarpus species demonstrate differential specificity. Mol Immunol. 1991; 28(4-5):393-8. DOI: 10.1016/0161-5890(91)90152-a. View

Parasuraman P, Murugan V, Selvin J, Gromiha M, Fukui K, Veluraja K . Insights into the binding specificity of wild type and mutated wheat germ agglutinin towards Neu5Acα(2-3)Gal: a study by in silico mutations and molecular dynamics simulations. J Mol Recognit. 2014; 27(8):482-92. DOI: 10.1002/jmr.2369. View

Wang H, Li H, Zhang W, Wei L, Yu H, Yang P . Multiplex profiling of glycoproteins using a novel bead-based lectin array. Proteomics. 2013; 14(1):78-86. DOI: 10.1002/pmic.201200544. View

Reddi A, Sankaranarayanan K, Arulraj H, Devaraj N, Devaraj H . Enzyme-linked PNA lectin-binding assay of serum T-antigen in patients with SCC of the uterine cervix. Cancer Lett. 2000; 149(1-2):207-11. DOI: 10.1016/s0304-3835(99)00363-8. View

Jagtap U, Bapat V . Artocarpus: a review of its traditional uses, phytochemistry and pharmacology. J Ethnopharmacol. 2010; 129(2):142-66. DOI: 10.1016/j.jep.2010.03.031. View

10.

Heim C, Hertzberg H, Butschi A, Bleuler-Martinez S, Aebi M, Deplazes P . Inhibition of Haemonchus contortus larval development by fungal lectins. Parasit Vectors. 2015; 8:425. PMC: 4539729. DOI: 10.1186/s13071-015-1032-x. View

11.

Hage D, Anguizola J, Bi C, Li R, Matsuda R, Papastavros E . Pharmaceutical and biomedical applications of affinity chromatography: recent trends and developments. J Pharm Biomed Anal. 2012; 69:93-105. PMC: 3346860. DOI: 10.1016/j.jpba.2012.01.004. View

12.

Li Y, Tao S, Bova G, Liu A, Chan D, Zhu H . Detection and verification of glycosylation patterns of glycoproteins from clinical specimens using lectin microarrays and lectin-based immunosorbent assays. Anal Chem. 2011; 83(22):8509-16. PMC: 3258529. DOI: 10.1021/ac201452f. View

13.

Bellei E, Bergamini S, Monari E, Fantoni L, Cuoghi A, Ozben T . High-abundance proteins depletion for serum proteomic analysis: concomitant removal of non-targeted proteins. Amino Acids. 2010; 40(1):145-56. DOI: 10.1007/s00726-010-0628-x. View

14.

Konami Y, Yamamoto K, Osawa T, Irimura T . Strong affinity of Maackia amurensis hemagglutinin (MAH) for sialic acid-containing Ser/Thr-linked carbohydrate chains of N-terminal octapeptides from human glycophorin A. FEBS Lett. 1994; 342(3):334-8. DOI: 10.1016/0014-5793(94)80527-x. View

15.

Coriolano M, de Melo C, Silva F, Schirato G, Porto C, Dos Santos P . Parkia pendula seed lectin: potential use to treat cutaneous wounds in healthy and immunocompromised mice. Appl Biochem Biotechnol. 2014; 172(5):2682-93. DOI: 10.1007/s12010-013-0692-2. View

16.

Lim S, Chua C, Hashim O . Isolation of a mannose-binding and IgE- and IgM-reactive lectin from the seeds of Artocarpus integer. J Immunol Methods. 1998; 209(2):177-86. DOI: 10.1016/s0022-1759(97)00158-0. View

17.

Tobata-Kudo H, Kudo H, Tada I . Strongyloides ratti: chemokinesis of glycolytic enzyme- and lectin-treated third-stage infective larvae in vitro. Parasitol Int. 2005; 54(2):147-52. DOI: 10.1016/j.parint.2005.03.001. View

18.

Thompson I, Pauler D, Goodman P, Tangen C, Lucia M, Parnes H . Prevalence of prostate cancer among men with a prostate-specific antigen level < or =4.0 ng per milliliter. N Engl J Med. 2004; 350(22):2239-46. DOI: 10.1056/NEJMoa031918. View

19.

Chan Y, Yu H, Xia L, Ng T . Lectin from green speckled lentil seeds (Lens culinaris) triggered apoptosis in nasopharyngeal carcinoma cell lines. Chin Med. 2015; 10:25. PMC: 4563850. DOI: 10.1186/s13020-015-0057-6. View

20.

Kim H, Lee S, Kim H . Antibody-based enzyme-linked lectin assay (ABELLA) for the sialylated recombinant human erythropoietin present in culture supernatant. J Pharm Biomed Anal. 2008; 48(3):716-21. DOI: 10.1016/j.jpba.2008.07.004. View