Effects of Polyphenol Intake on Metabolic Syndrome: Current Evidences from Human Trials

Overview

Journal Oxid Med Cell Longev

Publisher Wiley

Specialties Cell Biology
Endocrinology

Date 2017 Sep 13

PMID 28894509

Citations 78

Authors

Gemma Chiva-Blanch

Lina Badimon

Affiliations

Soon will be listed here.

Abstract

Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors which severely increases the risk of type II diabetes and cardiovascular disease. Several epidemiological studies have observed a negative association between polyphenol intake and MetS rates. Nevertheless, there are relatively small numbers of interventional studies evidencing this association. This review is focused on human interventional trials with polyphenols as polyphenol-rich foods and dietary patterns rich in polyphenols in patients with MetS. Current evidence suggests that polyphenol intake has the potential to alleviate MetS components by decreasing body weight, blood pressure, and blood glucose and by improving lipid metabolism. Therefore, high intake of polyphenol-rich foods such as nuts, fruits, vegetables, seasoning with aromatic plants, spices, and virgin olive oil may be the cornerstone of a healthy diet preventing the development and progression of MetS, although there is no polyphenol or polyphenol-rich food able to influence all MetS features. However, inconsistent results have been found in different trials, and more long-term randomized trials are warranted to develop public health strategies to decrease MetS rates.

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References

Tresserra-Rimbau A, Medina-Remon A, Lamuela-Raventos R, Bullo M, Salas-Salvado J, Corella D . Moderate red wine consumption is associated with a lower prevalence of the metabolic syndrome in the PREDIMED population. Br J Nutr. 2015; 113 Suppl 2:S121-30. DOI: 10.1017/S0007114514003262. View

Venturini D, Simao A, Urbano M, Dichi I . Effects of extra virgin olive oil and fish oil on lipid profile and oxidative stress in patients with metabolic syndrome. Nutrition. 2015; 31(6):834-40. DOI: 10.1016/j.nut.2014.12.016. View

Sperling L, Mechanick J, Neeland I, Herrick C, Despres J, Ndumele C . The CardioMetabolic Health Alliance: Working Toward a New Care Model for the Metabolic Syndrome. J Am Coll Cardiol. 2015; 66(9):1050-67. DOI: 10.1016/j.jacc.2015.06.1328. View

Eckel R, Grundy S, Zimmet P . The metabolic syndrome. Lancet. 2005; 365(9468):1415-28. DOI: 10.1016/S0140-6736(05)66378-7. View

Gothai S, Ganesan P, Park S, Fakurazi S, Choi D, Arulselvan P . Natural Phyto-Bioactive Compounds for the Treatment of Type 2 Diabetes: Inflammation as a Target. Nutrients. 2016; 8(8). PMC: 4997374. DOI: 10.3390/nu8080461. View

Rowland I, Faughnan M, Hoey L, Wahala K, Williamson G, Cassidy A . Bioavailability of phyto-oestrogens. Br J Nutr. 2003; 89 Suppl 1:S45-58. DOI: 10.1079/BJN2002796. View

Vazquez-Fresno R, Llorach R, Perera A, Mandal R, Feliz M, Tinahones F . Clinical phenotype clustering in cardiovascular risk patients for the identification of responsive metabotypes after red wine polyphenol intake. J Nutr Biochem. 2016; 28:114-20. DOI: 10.1016/j.jnutbio.2015.10.002. View

Nettleton J, Harnack L, Scrafford C, Mink P, Barraj L, Jacobs Jr D . Dietary flavonoids and flavonoid-rich foods are not associated with risk of type 2 diabetes in postmenopausal women. J Nutr. 2006; 136(12):3039-45. PMC: 3034085. DOI: 10.1093/jn/136.12.3039. View

Bai W, Wang C, Ren C . Intakes of total and individual flavonoids by US adults. Int J Food Sci Nutr. 2013; 65(1):9-20. DOI: 10.3109/09637486.2013.832170. View

10.

Wang D, Chen C, Wang Y, Liu J, Lin R . Effect of black tea consumption on blood cholesterol: a meta-analysis of 15 randomized controlled trials. PLoS One. 2014; 9(9):e107711. PMC: 4169558. DOI: 10.1371/journal.pone.0107711. View

11.

Fernandez-Quintela A, Carpene C, Fernandez M, Aguirre L, Milton-Laskibar I, Contreras J . Anti-obesity effects of resveratrol: comparison between animal models and humans. J Physiol Biochem. 2016; 73(3):417-429. DOI: 10.1007/s13105-016-0544-y. View

12.

DArchivio M, Filesi C, Di Benedetto R, Gargiulo R, Giovannini C, Masella R . Polyphenols, dietary sources and bioavailability. Ann Ist Super Sanita. 2008; 43(4):348-61. View

13.

Alberti K, Zimmet P, Shaw J . Metabolic syndrome--a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet Med. 2006; 23(5):469-80. DOI: 10.1111/j.1464-5491.2006.01858.x. View

14.

Zamora-Ros R, Forouhi N, Sharp S, Gonzalez C, Buijsse B, Guevara M . Dietary intakes of individual flavanols and flavonols are inversely associated with incident type 2 diabetes in European populations. J Nutr. 2013; 144(3):335-43. PMC: 3927546. DOI: 10.3945/jn.113.184945. View

15.

Basu A, Du M, Sanchez K, Leyva M, Betts N, Blevins S . Green tea minimally affects biomarkers of inflammation in obese subjects with metabolic syndrome. Nutrition. 2010; 27(2):206-13. PMC: 2952043. DOI: 10.1016/j.nut.2010.01.015. View

16.

Brat P, George S, Bellamy A, Du Chaffaut L, Scalbert A, Mennen L . Daily polyphenol intake in France from fruit and vegetables. J Nutr. 2006; 136(9):2368-73. DOI: 10.1093/jn/136.9.2368. View

17.

Babio N, Toledo E, Estruch R, Ros E, Martinez-Gonzalez M, Castaner O . Mediterranean diets and metabolic syndrome status in the PREDIMED randomized trial. CMAJ. 2014; 186(17):E649-57. PMC: 4234734. DOI: 10.1503/cmaj.140764. View

18.

Bekkouche L, Bouchenak M, Malaisse W, Yahia D . The Mediterranean diet adoption improves metabolic, oxidative, and inflammatory abnormalities in Algerian metabolic syndrome patients. Horm Metab Res. 2014; 46(4):274-82. DOI: 10.1055/s-0033-1363657. View

19.

Beking K, Vieira A . An assessment of dietary flavonoid intake in the UK and Ireland. Int J Food Sci Nutr. 2010; 62(1):17-9. DOI: 10.3109/09637486.2010.511165. View

20.

Barona J, Aristizabal J, Blesso C, Volek J, Fernandez M . Grape polyphenols reduce blood pressure and increase flow-mediated vasodilation in men with metabolic syndrome. J Nutr. 2012; 142(9):1626-32. DOI: 10.3945/jn.112.162743. View