Human Oncogenic Viruses: Nature and Discovery

Overview

Journal Philos Trans R Soc Lond B Biol Sci

Specialty Biology

Date 2017 Sep 13

PMID 28893931

Citations 49

Authors

Yuan Chang

Patrick S Moore

Robin A Weiss

Affiliations

Soon will be listed here.

Abstract

Seven kinds of virus collectively comprise an important cause of cancer, particularly in less developed countries and for people with damaged immune systems. Discovered over the past 54 years, most of these viruses are common infections of humankind for which malignancy is a rare consequence. Various cofactors affect the complex interaction between virus and host and the likelihood of cancer emerging. Although individual human tumour viruses exert their malignant effects in different ways, there are common features that illuminate mechanisms of oncogenesis more generally, whether or not there is a viral aetiology.This article is part of the themed issue 'Human oncogenic viruses'.

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References

Tommasino M . The biology of beta human papillomaviruses. Virus Res. 2016; 231:128-138. DOI: 10.1016/j.virusres.2016.11.013. View

Stracker T, Carson C, Weitzman M . Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex. Nature. 2002; 418(6895):348-52. DOI: 10.1038/nature00863. View

Lieberman P . Virology. Epstein-Barr virus turns 50. Science. 2014; 343(6177):1323-5. PMC: 4581426. DOI: 10.1126/science.1252786. View

Coffin J, Varmus H, Bishop J, Essex M, Hardy Jr W, Martin G . Proposal for naming host cell-derived inserts in retrovirus genomes. J Virol. 1981; 40(3):953-7. PMC: 256709. DOI: 10.1128/JVI.40.3.953-957.1981. View

Moore P, Chang Y . Antiviral activity of tumor-suppressor pathways: clues from molecular piracy by KSHV. Trends Genet. 1998; 14(4):144-50. DOI: 10.1016/s0168-9525(98)01408-5. View

Cook-Mozaffari P, Newton R, Beral V, Burkitt D . The geographical distribution of Kaposi's sarcoma and of lymphomas in Africa before the AIDS epidemic. Br J Cancer. 1998; 78(11):1521-8. PMC: 2063225. DOI: 10.1038/bjc.1998.717. View

Paprotka T, Delviks-Frankenberry K, Cingoz O, Martinez A, Kung H, Tepper C . Recombinant origin of the retrovirus XMRV. Science. 2011; 333(6038):97-101. PMC: 3278917. DOI: 10.1126/science.1205292. View

Lane D, CRAWFORD L . T antigen is bound to a host protein in SV40-transformed cells. Nature. 1979; 278(5701):261-3. DOI: 10.1038/278261a0. View

Guo Z, Liu Z, Kowalsky S, Feist M, Kalinski P, Lu B . Oncolytic Immunotherapy: Conceptual Evolution, Current Strategies, and Future Perspectives. Front Immunol. 2017; 8:555. PMC: 5430078. DOI: 10.3389/fimmu.2017.00555. View

10.

Sbolli G, Zanetti A, Tanzi E, Cavanna L, Civardi G, Fornari F . Serum antibodies to hepatitis C virus in Italian patients with hepatocellular carcinoma. J Med Virol. 1990; 30(3):230-2. DOI: 10.1002/jmv.1890300316. View

11.

Moore P, Chang Y . The conundrum of causality in tumor virology: the cases of KSHV and MCV. Semin Cancer Biol. 2013; 26:4-12. PMC: 4040341. DOI: 10.1016/j.semcancer.2013.11.001. View

12.

Viscidi R, Clayman B . Serological cross reactivity between polyomavirus capsids. Adv Exp Med Biol. 2006; 577:73-84. DOI: 10.1007/0-387-32957-9_5. View

13.

Mariggio G, Koch S, Schulz T . Kaposi sarcoma herpesvirus pathogenesis. Philos Trans R Soc Lond B Biol Sci. 2017; 372(1732). PMC: 5597742. DOI: 10.1098/rstb.2016.0275. View

14.

Moore P, Chang Y . Kaposi's sarcoma-associated herpesvirus immunoevasion and tumorigenesis: two sides of the same coin?. Annu Rev Microbiol. 2003; 57:609-39. PMC: 3732455. DOI: 10.1146/annurev.micro.57.030502.090824. View

15.

Chang Y, Moore P . Merkel cell carcinoma: a virus-induced human cancer. Annu Rev Pathol. 2011; 7:123-44. PMC: 3732449. DOI: 10.1146/annurev-pathol-011110-130227. View

16.

Parkin D . The global health burden of infection-associated cancers in the year 2002. Int J Cancer. 2006; 118(12):3030-44. DOI: 10.1002/ijc.21731. View

17.

Levine A . The common mechanisms of transformation by the small DNA tumor viruses: The inactivation of tumor suppressor gene products: p53. Virology. 2008; 384(2):285-93. DOI: 10.1016/j.virol.2008.09.034. View

18.

Feng H, Shuda M, Chang Y, Moore P . Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science. 2008; 319(5866):1096-100. PMC: 2740911. DOI: 10.1126/science.1152586. View

19.

Cesarman E, Chang Y, Moore P, Said J, Knowles D . Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N Engl J Med. 1995; 332(18):1186-91. DOI: 10.1056/NEJM199505043321802. View

20.

Ganem D, Prince A . Hepatitis B virus infection--natural history and clinical consequences. N Engl J Med. 2004; 350(11):1118-29. DOI: 10.1056/NEJMra031087. View