Biology of Bone: The Vasculature of the Skeletal System

Overview

Journal Cold Spring Harb Perspect Med

Specialty General Medicine

Date 2017 Sep 13

PMID 28893838

Citations 58

Authors

Emma C Watson

Ralf H Adams

Affiliations

Soon will be listed here.

Abstract

Blood vessels are essential for the distribution of oxygen, nutrients, and immune cells, as well as the removal of waste products. In addition to this conventional role as a versatile conduit system, the endothelial cells forming the innermost layer of the vessel wall also possess important signaling capabilities and can control growth, patterning, homeostasis, and regeneration of the surrounding organ. In the skeletal system, blood vessels regulate developmental and regenerative bone formation as well as hematopoiesis by providing vascular niches for hematopoietic stem cells. Here we provide an overview of blood vessel architecture, growth and properties in the healthy, aging, and diseased skeletal system.

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