Low Rate of Genotype Among Iranian Clinical Isolates

Overview

Journal J Clin Diagn Res

Specialty General Medicine

Date 2017 Sep 13

PMID 28892894

Citations 4

Authors

Maryam Sohrabi

Reza Khashei

Mahvash Alizadeh

Mohammad-Kazem Hosseini Asl

Mohammad-Ali Nejati

Mahintaj Dara

Abdollah Bazargani

Affiliations

Soon will be listed here.

Abstract

Introduction: The Blood Group Antigen-Binding Adhesion (), Outer Inflammatory Protein () and Sialic Acid-Binding Adhesin () as outer membrane proteins involved in adherence to gastric mucosa have been suggested to have a role in the pathogenesis.

Aim: To investigate the frequency of isolates , and genes in Iranian dyspeptic patients.

Materials And Methods: DNAs were extracted from -positive cultures taken from 100 different dyspeptic patients. Genotyping was performed by Polymerase Chain Reaction (PCR), using the specific primers for , and genes. Chi square test was used to investigate association between variables, p<0.05 was considered statistically significant.

Results: All (100%) isolates possessed and genotypes, whereas was detected in 22% of isolates. There was no significant relationship between presence of genes with clinical outcome. The combined genotype +/ +/ - was correlated with gastritis. The rate of genotype in our isolates was lower than other Iranian reports.

Conclusion: Frequency of genotype among isolates from Southwest of Iran is considerably less than other regions of Iran. Due to heterogeneity of strains in different geographic regions, further work will be needed to understand the role of these virulence genes in pathogenesis and their possible association with disease outcome.

Citing Articles

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