Target Product Profiles for the Diagnosis of Taenia Solium Taeniasis, Neurocysticercosis and Porcine Cysticercosis

Overview

Journal PLoS Negl Trop Dis

Specialties Infectious Diseases
Tropical Medicine

Date 2017 Sep 12

PMID 28892472

Citations 30

Authors

Meritxell Donadeu

Anna S Fahrion

Piero L Olliaro

Bernadette Abela-Ridder

Affiliations

Soon will be listed here.

Abstract

Target Product Profiles (TPPs) are process tools providing product requirements to guide researchers, developers and manufacturers in their efforts to develop effective and useful products such as biologicals, drugs or diagnostics. During a WHO Stakeholders Meeting on Taenia solium diagnostics, several TPPs were initiated to address diagnostic needs for different stages in the parasite's transmission (taeniasis, human and porcine cysticercosis). Following the meeting, draft TPPs were completed and distributed for consultation to 100 people/organizations, including experts in parasitology, human and pig cysticercosis, diagnostic researchers and manufacturers, international organizations working with neglected or zoonotic diseases, Ministries of Health and Ministries of Livestock in some of the endemic countries, WHO regional offices and other interested parties. There were 53 respondents. All comments and feedback received were considered and discussions were held with different experts according to their area of expertise. The comments were consolidated and final TPPs are presented here. They are considered to be live documents which are likely to undergo review and updating in the future when new knowledge and technologies become available.

Citing Articles

The performance of a point-of-care test for the diagnosis of Neurocysticercosis in a resource-poor community setting in Zambia - a diagnostic accuracy study.

Zulu G, Stelzle D, Mwape K, Van Damme I, Trevisan C, Mubanga C EClinicalMedicine. 2024; 77:102893.

PMID: 39552715 PMC: 11567943. DOI: 10.1016/j.eclinm.2024.102893.

Accuracy of immunological tests on serum and urine for diagnosis of Taenia solium neurocysticercosis: A systematic review.

Van Acker L, Toribio L, Chachage M, Zeng H, Devleesschauwer B, Garcia H PLoS Negl Trop Dis. 2024; 18(11):e0012643.

PMID: 39527651 PMC: 11581404. DOI: 10.1371/journal.pntd.0012643.

High prevalence of porcine cysticercosis in slaughtered pigs in Rwanda: An abattoir survey.

Shyaka A, Rujeni N, Kanyamibwa E, Kagabo G, Fevre E, Quinnell R PLoS Negl Trop Dis. 2024; 18(10):e0012598.

PMID: 39453982 PMC: 11540212. DOI: 10.1371/journal.pntd.0012598.

Facilitating the use of the target product profile in academic research: a systematic review.

Ibnidris A, Liaskos N, Eldem E, Gunn A, Streffer J, Gold M J Transl Med. 2024; 22(1):693.

PMID: 39075460 PMC: 11288132. DOI: 10.1186/s12967-024-05476-1.

Antibody Banding Patterns on the Enzyme-Linked Immunoelectrotransfer Blot (EITB) Assay Clearly Discriminate Viable Cysticercosis in Naturally Infected Pigs.

Arroyo G, Lescano A, Gavidia C, Lopez-Urbina T, Ara-Gomez M, Gomez-Puerta L Pathogens. 2024; 13(1).

PMID: 38251323 PMC: 10820179. DOI: 10.3390/pathogens13010015.

References

Nash T, Bustos J, Garcia H . Disease Centered Around Calcified Taenia solium Granuloma. Trends Parasitol. 2016; 33(1):65-73. PMC: 5203955. DOI: 10.1016/j.pt.2016.09.003. View

Dorny P, Phiri I, Vercruysse J, Gabriel S, Willingham 3rd A, Brandt J . A Bayesian approach for estimating values for prevalence and diagnostic test characteristics of porcine cysticercosis. Int J Parasitol. 2004; 34(5):569-76. DOI: 10.1016/j.ijpara.2003.11.014. View

Mwape K, Phiri I, Praet N, Speybroeck N, Muma J, Dorny P . The incidence of human cysticercosis in a rural community of Eastern Zambia. PLoS Negl Trop Dis. 2013; 7(3):e2142. PMC: 3605208. DOI: 10.1371/journal.pntd.0002142. View

Del Brutto O, Nash T, White Jr A, Rajshekhar V, Wilkins P, Singh G . Revised diagnostic criteria for neurocysticercosis. J Neurol Sci. 2016; 372:202-210. DOI: 10.1016/j.jns.2016.11.045. View

Gonzalez A, Bustos J, Garcia H, Rodriguez S, Zimic M, Castillo Y . Successful Antiparasitic Treatment for Cysticercosis is Associated with a Fast and Marked Reduction of Circulating Antigen Levels in a Naturally Infected Pig Model. Am J Trop Med Hyg. 2015; 93(6):1305-10. PMC: 4674250. DOI: 10.4269/ajtmh.15-0370. View

Jayashi C, Gonzalez A, Neyra R, Rodriguez S, Garcia H, Lightowlers M . Validity of the Enzyme-linked Immunoelectrotransfer Blot (EITB) for naturally acquired porcine cysticercosis. Vet Parasitol. 2013; 199(1-2):42-9. PMC: 5448663. DOI: 10.1016/j.vetpar.2013.10.004. View

Devleesschauwer B, Aryal A, Tharmalingam J, Joshi D, Rijal S, Speybroeck N . Complexities in using sentinel pigs to study Taenia solium transmission dynamics under field conditions. Vet Parasitol. 2013; 193(1-3):172-8. DOI: 10.1016/j.vetpar.2012.12.010. View

Lightowlers M, Garcia H, Gauci C, Donadeu M, Abela-Ridder B . Monitoring the outcomes of interventions against Taenia solium: options and suggestions. Parasite Immunol. 2015; 38(3):158-69. PMC: 4819694. DOI: 10.1111/pim.12291. View

Mahanty S, Garcia H . Cysticercosis and neurocysticercosis as pathogens affecting the nervous system. Prog Neurobiol. 2009; 91(2):172-84. DOI: 10.1016/j.pneurobio.2009.12.008. View

10.

Sikasunge C, Johansen M, Willingham 3rd A, Leifsson P, Phiri I . Taenia solium porcine cysticercosis: viability of cysticerci and persistency of antibodies and cysticercal antigens after treatment with oxfendazole. Vet Parasitol. 2008; 158(1-2):57-66. DOI: 10.1016/j.vetpar.2008.08.014. View

11.

Donadeu M, Lightowlers M, Fahrion A, Kessels J, Abela-Ridder B . Taenia solium: WHO endemicity map update. Wkly Epidemiol Rec. 2016; 91(49-50):595-9. View

12.

de Almeida S, Bleggi Torres L . Neurocysticercosis--retrospective study of autopsy reports, a 17-year experience. J Community Health. 2011; 36(5):698-702. DOI: 10.1007/s10900-011-9389-z. View

13.

Meza-Lucas A, Carmona-Miranda L, Garcia-Jeronimo R, Torrero-Miranda A, Gonzalez-Hidalgo G, Lopez-Castellanos G . Short report: limited and short-lasting humoral response in Taenia solium: seropositive households compared with patients with neurocysticercosis. Am J Trop Med Hyg. 2003; 69(2):223-7. View

14.

Guezala M, Rodriguez S, Zamora H, Garcia H, Gonzalez A, Tembo A . Development of a species-specific coproantigen ELISA for human Taenia solium taeniasis. Am J Trop Med Hyg. 2009; 81(3):433-7. View

15.

Mwanjali G, Kihamia C, Kakoko D, Lekule F, Ngowi H, Johansen M . Prevalence and risk factors associated with human Taenia solium infections in Mbozi District, Mbeya Region, Tanzania. PLoS Negl Trop Dis. 2013; 7(3):e2102. PMC: 3597471. DOI: 10.1371/journal.pntd.0002102. View

16.

Rajshekhar V . Neurocysticercosis: Diagnostic problems & current therapeutic strategies. Indian J Med Res. 2017; 144(3):319-326. PMC: 5320837. DOI: 10.4103/0971-5916.198686. View

17.

Allan J, Avila G, Garcia Noval J, Flisser A, Craig P . Immunodiagnosis of taeniasis by coproantigen detection. Parasitology. 1990; 101 Pt 3:473-7. DOI: 10.1017/s0031182000060686. View

18.

Carpio A, Fleury A, Romo M, Abraham R, Fandino J, Duran J . New diagnostic criteria for neurocysticercosis: Reliability and validity. Ann Neurol. 2016; 80(3):434-42. PMC: 5053253. DOI: 10.1002/ana.24732. View

19.

Garcia H, Nash T, Del Brutto O . Clinical symptoms, diagnosis, and treatment of neurocysticercosis. Lancet Neurol. 2014; 13(12):1202-15. PMC: 6108081. DOI: 10.1016/S1474-4422(14)70094-8. View

20.

Gavidia C, Verastegui M, Garcia H, Lopez-Urbina T, Tsang V, Pan W . Relationship between serum antibodies and Taenia solium larvae burden in pigs raised in field conditions. PLoS Negl Trop Dis. 2013; 7(5):e2192. PMC: 3642188. DOI: 10.1371/journal.pntd.0002192. View