Two-Step, One-Pot Synthesis of Visible-Light-Responsive 6-Azopurines

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2017 Sep 12

PMID 28891651

Citations 9

Authors

Dusan Kolarski

Wiktor Szymanski

Ben L Feringa

Affiliations

Soon will be listed here.

Abstract

The first general two-step, one-pot synthetic route to 6-azopurines is presented. Microwave-assisted nucleophilic aromatic substitution of protected 6-chloropurines with hydrazines or hydrazides, followed by metal-free oxidation with oxygen, gives 6-azopurines in high to excellent yields. Photophysical studies revealed intensive n-π* absorption band that makes trans-to-cis photoswitching possible using visible light (λ = 530 nm).

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