Influenza Virus Replication in Macrophages: Balancing Protection and Pathogenesis

Overview

Journal J Gen Virol

Specialty Microbiology

Date 2017 Sep 9

PMID 28884667

Citations 60

Authors

Troy D Cline

Donald Beck

Elizabeth Bianchini

Affiliations

Soon will be listed here.

Abstract

Macrophages are essential for protection against influenza A virus infection, but are also implicated in the morbidity and mortality associated with severe influenza disease, particularly during infection with highly pathogenic avian influenza (HPAI) H5N1 virus. While influenza virus infection of macrophages was once thought to be abortive, it is now clear that certain virus strains can replicate productively in macrophages. This may have important consequences for the antiviral functions of macrophages, the course of disease and the outcome of infection for the host. In this article, we review findings related to influenza virus replication in macrophages and the impact of productive replication on macrophage antiviral functions. A clear understanding of the interactions between influenza viruses and macrophages may lead to new antiviral therapies to relieve the burden of severe disease associated with influenza viruses.

Citing Articles

Pathogen class-specific transcriptional responses derived from PBMCs accurately discriminate between fungal, bacterial, and viral infections.

Steinbrink J, Liu Y, Henao R, Tsalik E, Ginsburg G, Ramsburg E PLoS One. 2024; 19(12):e0311007.

PMID: 39666613 PMC: 11637350. DOI: 10.1371/journal.pone.0311007.

Unraveling Macrophage Polarization: Functions, Mechanisms, and "Double-Edged Sword" Roles in Host Antiviral Immune Responses.

Yao M, Li M, Peng D, Wang Y, Li S, Zhang D Int J Mol Sci. 2024; 25(22).

PMID: 39596148 PMC: 11593441. DOI: 10.3390/ijms252212078.

Lauf T, Hader A, Hornung F, Reisser Y, Nietzsche S, Schanz F Immun Ageing. 2024; 21(1):80.

PMID: 39543713 PMC: 11562583. DOI: 10.1186/s12979-024-00482-9.

Leveraging a comprehensive unbiased RNAseq database to characterize human monocyte-derived macrophage gene expression profiles within commonly employed in vitro polarization methods.

Smyth T, Payton A, Hickman E, Rager J, Jaspers I Sci Rep. 2024; 14(1):26753.

PMID: 39500943 PMC: 11538326. DOI: 10.1038/s41598-024-78000-6.

Influence of Donor-Specific Characteristics on Cytokine Responses in H3N2 Influenza A Virus Infection: New Insights from an Ex Vivo Model.

Huang C, Hsieh M, Wu Y, Huang P, Lin Y, Tsao K Int J Mol Sci. 2024; 25(20).

PMID: 39456722 PMC: 11507259. DOI: 10.3390/ijms252010941.

References

Arredouani M, Yang Z, Imrich A, Ning Y, Qin G, Kobzik L . The macrophage scavenger receptor SR-AI/II and lung defense against pneumococci and particles. Am J Respir Cell Mol Biol. 2006; 35(4):474-8. PMC: 2643266. DOI: 10.1165/rcmb.2006-0128OC. View

Job E, Deng Y, Barfod K, Tate M, Caldwell N, Reddiex S . Addition of glycosylation to influenza A virus hemagglutinin modulates antibody-mediated recognition of H1N1 2009 pandemic viruses. J Immunol. 2013; 190(5):2169-77. DOI: 10.4049/jimmunol.1202433. View

Lee S, Gardy J, Cheung C, Cheung T, Hui K, Ip N . Systems-level comparison of host-responses elicited by avian H5N1 and seasonal H1N1 influenza viruses in primary human macrophages. PLoS One. 2009; 4(12):e8072. PMC: 2788213. DOI: 10.1371/journal.pone.0008072. View

Nelli R, Dunham S, Kuchipudi S, White G, Baquero-Perez B, Chang P . Mammalian innate resistance to highly pathogenic avian influenza H5N1 virus infection is mediated through reduced proinflammation and infectious virus release. J Virol. 2012; 86(17):9201-10. PMC: 3416141. DOI: 10.1128/JVI.00244-12. View

Marvin S, Russier M, Huerta C, Russell C, Schultz-Cherry S . Influenza Virus Overcomes Cellular Blocks To Productively Replicate, Impacting Macrophage Function. J Virol. 2016; 91(2). PMC: 5215328. DOI: 10.1128/JVI.01417-16. View

Rodgers B, Mims C . Interaction of influenza virus with mouse macrophages. Infect Immun. 1981; 31(2):751-7. PMC: 351374. DOI: 10.1128/iai.31.2.751-757.1981. View

Powe J, Castleman W . Canine influenza virus replicates in alveolar macrophages and induces TNF-alpha. Vet Pathol. 2009; 46(6):1187-96. DOI: 10.1354/vp.08-VP-0229-P-FL. View

Choi Y, Nguyen T, Ozaki H, Webby R, Puthavathana P, Buranathal C . Studies of H5N1 influenza virus infection of pigs by using viruses isolated in Vietnam and Thailand in 2004. J Virol. 2005; 79(16):10821-5. PMC: 1182619. DOI: 10.1128/JVI.79.16.10821-10825.2005. View

Steurbaut S, Merckx E, Rombaut B, Vrijsen R . Modulation of viral replication in macrophages persistently infected with the DA strain of Theiler's murine encephalomyelitis virus. Virol J. 2008; 5:89. PMC: 2515842. DOI: 10.1186/1743-422X-5-89. View

10.

Peiris J, de Jong M, Guan Y . Avian influenza virus (H5N1): a threat to human health. Clin Microbiol Rev. 2007; 20(2):243-67. PMC: 1865597. DOI: 10.1128/CMR.00037-06. View

11.

Sakabe S, Iwatsuki-Horimoto K, Takano R, Nidom C, Le M, Nagamura-Inoue T . Cytokine production by primary human macrophages infected with highly pathogenic H5N1 or pandemic H1N1 2009 influenza viruses. J Gen Virol. 2011; 92(Pt 6):1428-1434. PMC: 3168279. DOI: 10.1099/vir.0.030346-0. View

12.

Lipatov A, Kwon Y, Sarmento L, Lager K, Spackman E, Suarez D . Domestic pigs have low susceptibility to H5N1 highly pathogenic avian influenza viruses. PLoS Pathog. 2008; 4(7):e1000102. PMC: 2438613. DOI: 10.1371/journal.ppat.1000102. View

13.

Reading P, Miller J, Anders E . Involvement of the mannose receptor in infection of macrophages by influenza virus. J Virol. 2000; 74(11):5190-7. PMC: 110872. DOI: 10.1128/jvi.74.11.5190-5197.2000. View

14.

Mok C, Lee D, Cheung C, Peiris M, Lau A . Differential onset of apoptosis in influenza A virus H5N1- and H1N1-infected human blood macrophages. J Gen Virol. 2007; 88(Pt 4):1275-1280. DOI: 10.1099/vir.0.82423-0. View

15.

Wang J, Nikrad M, Travanty E, Zhou B, Phang T, Gao B . Innate immune response of human alveolar macrophages during influenza A infection. PLoS One. 2012; 7(3):e29879. PMC: 3292548. DOI: 10.1371/journal.pone.0029879. View

16.

Campbell G, Nicol M, Dransfield I, Shaw D, Nash A, Dutia B . Susceptibility of bone marrow-derived macrophages to influenza virus infection is dependent on macrophage phenotype. J Gen Virol. 2015; 96(10):2951-2960. PMC: 4635478. DOI: 10.1099/jgv.0.000240. View

17.

Kim H, Lee Y, Lee K, Kim H, Cho S, van Rooijen N . Alveolar macrophages are indispensable for controlling influenza viruses in lungs of pigs. J Virol. 2008; 82(9):4265-74. PMC: 2293066. DOI: 10.1128/JVI.02602-07. View

18.

Kobasa D, Jones S, Shinya K, Kash J, Copps J, Ebihara H . Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus. Nature. 2007; 445(7125):319-23. DOI: 10.1038/nature05495. View

19.

Zhou J, Fang D, Fu J, Tian J, Zhou J, Yan H . Infection and replication of avian influenza H5N1 virus in an infected human. Virus Genes. 2009; 39(1):76-80. PMC: 7101767. DOI: 10.1007/s11262-009-0365-y. View

20.

Meng B, Marriott A, Dimmock N . The receptor preference of influenza viruses. Influenza Other Respir Viruses. 2010; 4(3):147-53. PMC: 4941662. DOI: 10.1111/j.1750-2659.2010.00130.x. View