The Role of MiRNAs As Biomarkers for Pregnancy Outcomes: A Comprehensive Review

Overview

Journal Int J Genomics

Publisher Wiley

Date 2017 Sep 9

PMID 28884117

Citations 38

Authors

Martina Barchitta

Andrea Maugeri

Annalisa Quattrocchi

Ottavia Agrifoglio

Antonella Agodi

Affiliations

Soon will be listed here.

Abstract

Several studies showed that altered expression of the miRNA-ome in maternal circulation or in placental tissue may reflect not only gestational disorders, such as preeclampsia, spontaneous abortion, preterm birth, low birth weight, or macrosomia, but also prenatal exposure to environmental pollutants. Generally, the relationships between environmental exposure, changes in miRNA expression, and gestational disorders are explored separately, producing conflicting findings. However, validation of tissue-accessible biomarkers for the monitoring of adverse pregnancy outcomes needs a systematic methodological approach that takes also into account early-life environmental exposure. To achieve this goal, exposure to xenochemicals, endogenous agents, and diet should be assessed. This study has the aim to provide a comprehensive review on the role of miRNAs as potential biomarkers for adverse pregnancy outcomes and prenatal environmental exposure.

Citing Articles

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The Effect of Physical Activity/Exercise on miRNA Expression and Function in Non-Communicable Diseases-A Systematic Review.

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