Gold Nanoparticles Enlighten the Future of Cancer Theranostics

Overview

Journal Int J Nanomedicine

Publisher Dove Medical Press

Specialty Biotechnology

Date 2017 Sep 9

PMID 28883725

Citations 68

Authors

Jianfeng Guo

Kamil Rahme

Yan He

Lin-Lin Li

Justin D Holmes

Caitriona M ODriscoll

Affiliations

Soon will be listed here.

Abstract

Development of multifunctional nanomaterials, one of the most interesting and advanced research areas in the field of nanotechnology, is anticipated to revolutionize cancer diagnosis and treatment. Gold nanoparticles (AuNPs) are now being widely utilized in bio-imaging and phototherapy due to their tunable and highly sensitive optical and electronic properties (the surface plasmon resonance). As a new concept, termed "theranostics," multifunctional AuNPs may contain diagnostic and therapeutic functions that can be integrated into one system, thereby simultaneously facilitating diagnosis and therapy and monitoring therapeutic responses. In this review, the important properties of AuNPs relevant to diagnostic and phototherapeutic applications such as structure, shape, optics, and surface chemistry are described. Barriers for translational development of theranostic AuNPs and recent advances in the application of AuNPs for cancer diagnosis, photothermal, and photodynamic therapy are discussed.

Citing Articles

A state-of-the-art review of the recent advances of theranostic liposome hybrid nanoparticles in cancer treatment and diagnosis.

Azimizonuzi H, Ghayourvahdat A, Ahmed M, Kareem R, Jaber Zrzor A, Mansoor A Cancer Cell Int. 2025; 25(1):26.

PMID: 39871316 PMC: 11773959. DOI: 10.1186/s12935-024-03610-z.

Nanotherapeutics for Macrophage Network Modulation in Tumor Microenvironments: Targets and Tools.

Li R, Huang J, Wei Y, Wang Y, Lu C, Liu J Int J Nanomedicine. 2024; 19:13615-13651.

PMID: 39717515 PMC: 11665441. DOI: 10.2147/IJN.S491573.

Tackling breast cancer with gold nanoparticles: twinning synthesis and particle engineering with efficacy.

Mal S, Chakraborty S, Mahapatra M, Pakeeraiah K, Das S, Paidesetty S Nanoscale Adv. 2024; 6(11):2766-2812.

PMID: 38817429 PMC: 11134266. DOI: 10.1039/d3na00988b.

Lectin: A Molecular Tool in Cancer Diagnosis and Therapy with Special Reference to Reproductive Cancers.

Pallar R, Pingle S, Gaikwad A, Yennam N, Raju N, Kumar P Mol Biotechnol. 2024; 67(2):456-468.

PMID: 38456960 DOI: 10.1007/s12033-024-01086-w.

Theranostics: a multifaceted approach utilizing nano-biomaterials.

Yasir M, Mishra R, Tripathi A, Maurya R, Shahi A, Zaki M Discov Nano. 2024; 19(1):35.

PMID: 38407670 PMC: 10897124. DOI: 10.1186/s11671-024-03979-w.

References

Zhang P, Yang X, Wang Y, Zhao N, Xiong Z, Huang C . Rapid synthesis of highly luminescent and stable Au20 nanoclusters for active tumor-targeted imaging in vitro and in vivo. Nanoscale. 2014; 6(4):2261-9. DOI: 10.1039/c3nr05269a. View

Li X, Takashima M, Yuba E, Harada A, Kono K . PEGylated PAMAM dendrimer-doxorubicin conjugate-hybridized gold nanorod for combined photothermal-chemotherapy. Biomaterials. 2014; 35(24):6576-84. DOI: 10.1016/j.biomaterials.2014.04.043. View

Hu H, Huang P, Weiss O, Yan X, Yue X, Zhang M . PET and NIR optical imaging using self-illuminating (64)Cu-doped chelator-free gold nanoclusters. Biomaterials. 2014; 35(37):9868-9876. PMC: 4180787. DOI: 10.1016/j.biomaterials.2014.08.038. View

Jokerst J, Cole A, Van de Sompel D, Gambhir S . Gold nanorods for ovarian cancer detection with photoacoustic imaging and resection guidance via Raman imaging in living mice. ACS Nano. 2012; 6(11):10366-77. PMC: 3572720. DOI: 10.1021/nn304347g. View

Chen Q, Li K, Wen S, Liu H, Peng C, Cai H . Targeted CT/MR dual mode imaging of tumors using multifunctional dendrimer-entrapped gold nanoparticles. Biomaterials. 2013; 34(21):5200-9. DOI: 10.1016/j.biomaterials.2013.03.009. View

Khoury C, Vo-Dinh T . Gold Nanostars For Surface-Enhanced Raman Scattering: Synthesis, Characterization and Optimization. J Phys Chem C Nanomater Interfaces. 2013; 2008(112):18849-18859. PMC: 3748989. DOI: 10.1021/jp8054747. View

Tong L, Wei Q, Wei A, Cheng J . Gold nanorods as contrast agents for biological imaging: optical properties, surface conjugation and photothermal effects. Photochem Photobiol. 2009; 85(1):21-32. PMC: 2818790. DOI: 10.1111/j.1751-1097.2008.00507.x. View

Paul A, Fan Z, Sinha S, Shi Y, Le L, Bai F . Bio-Conjugated Gold Nanoparticle Based SERS Probe for Ultrasensitive Identification of Mosquito-Borne Viruses Using Raman Fingerprinting. J Phys Chem C Nanomater Interfaces. 2016; 119(41):23669-23775. PMC: 4948854. DOI: 10.1021/acs.jpcc.5b07387. View

Lu W, Melancon M, Xiong C, Huang Q, Elliott A, Song S . Effects of photoacoustic imaging and photothermal ablation therapy mediated by targeted hollow gold nanospheres in an orthotopic mouse xenograft model of glioma. Cancer Res. 2011; 71(19):6116-21. PMC: 3185126. DOI: 10.1158/0008-5472.CAN-10-4557. View

10.

Chen R, Wang X, Yao X, Zheng X, Wang J, Jiang X . Near-IR-triggered photothermal/photodynamic dual-modality therapy system via chitosan hybrid nanospheres. Biomaterials. 2013; 34(33):8314-22. DOI: 10.1016/j.biomaterials.2013.07.034. View

11.

Zhang Z, Wang J, Nie X, Wen T, Ji Y, Wu X . Near infrared laser-induced targeted cancer therapy using thermoresponsive polymer encapsulated gold nanorods. J Am Chem Soc. 2014; 136(20):7317-26. DOI: 10.1021/ja412735p. View

12.

Khlebtsov N, Dykman L . Biodistribution and toxicity of engineered gold nanoparticles: a review of in vitro and in vivo studies. Chem Soc Rev. 2010; 40(3):1647-71. DOI: 10.1039/c0cs00018c. View

13.

Riley R, Day E . Gold nanoparticle-mediated photothermal therapy: applications and opportunities for multimodal cancer treatment. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2017; 9(4). PMC: 5474189. DOI: 10.1002/wnan.1449. View

14.

Huang S, Li C, Wang W, Li H, Sun Z, Song C . A54 peptide-mediated functionalized gold nanocages for targeted delivery of DOX as a combinational photothermal-chemotherapy for liver cancer. Int J Nanomedicine. 2017; 12:5163-5176. PMC: 5529379. DOI: 10.2147/IJN.S131089. View

15.

Cheng B, He H, Huang T, Berr S, He J, Fan D . Gold Nanosphere Gated Mesoporous Silica Nanoparticle Responsive to Near-Infrared Light and Redox Potential as a Theranostic Platform for Cancer Therapy. J Biomed Nanotechnol. 2016; 12(3):435-49. PMC: 4776644. DOI: 10.1166/jbn.2016.2195. View

16.

Ryu J, Koo H, Sun I, Yuk S, Choi K, Kim K . Tumor-targeting multi-functional nanoparticles for theragnosis: new paradigm for cancer therapy. Adv Drug Deliv Rev. 2012; 64(13):1447-58. DOI: 10.1016/j.addr.2012.06.012. View

17.

Wang B, Wang J, Liu Q, Huang H, Chen M, Li K . Rose-bengal-conjugated gold nanorods for in vivo photodynamic and photothermal oral cancer therapies. Biomaterials. 2013; 35(6):1954-66. DOI: 10.1016/j.biomaterials.2013.11.066. View

18.

Liu X, Xu H, Xia H, Wang D . Rapid seeded growth of monodisperse, quasi-spherical, citrate-stabilized gold nanoparticles via H2O2 reduction. Langmuir. 2012; 28(38):13720-6. DOI: 10.1021/la3027804. View

19.

Hanahan D, Weinberg R . Hallmarks of cancer: the next generation. Cell. 2011; 144(5):646-74. DOI: 10.1016/j.cell.2011.02.013. View

20.

Hleb E, Hafner J, Myers J, Hanna E, Rostro B, Zhdanok S . LANTCET: elimination of solid tumor cells with photothermal bubbles generated around clusters of gold nanoparticles. Nanomedicine (Lond). 2008; 3(5):647-67. DOI: 10.2217/17435889.3.5.647. View