The Clinical and Prognostic Value of CXCL8 in Cervical Carcinoma Patients: Immunohistochemical Analysis

Overview

Journal Biosci Rep

Specialty Cell Biology

Date 2017 Sep 9

PMID 28883082

Citations 16

Authors

Ruiling Yan

Hanlin Shuai

Xin Luo

Xueqin Wang

Baozhang Guan

Affiliations

Soon will be listed here.

Abstract

Cysteine-X-cysteine ligand 8 (CXCL8) was originally discovered as a proinflammatory chemokine. Recently, CXCL8 has been shown to act as an oncogene in several types of human cancers. However, the clinical and prognostic significance of CXCL8 in cervical cancer is poorly understood. In our study, we found that CXCL8 was highly expressed in cervical cancer tissues compared with normal cervical tissues in microarray datasets (GSE9750 and GSE7803). mRNA and protein expressions were increased in cervical cancer tissues and cell lines compared with normal cervical tissues and cervical epithelial cell lines. CXCL8 protein expression was significantly correlated with clinical stage, distant metastasis, histological type, and histological grade. CXCL8 high expression was a poor independent prognostic parameter for cervical cancer patients. In conclusion, CXCL8 is highly expressed in cervical cancer tissues and cell lines, and correlated with malignant status and prognosis in cervical cancer patients.

Citing Articles

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