Gene Polymorphisms and HDL Subfractions in Coronary Artery Disease

Overview

Journal In Vivo

Specialty Oncology

Date 2017 Sep 9

PMID 28882953

Citations 4

Authors

Huseyin Ayhan

Uzay Gormus

Selim Isbir

Seda Gulec Yilmaz

Turgay Isbir

Affiliations

Soon will be listed here.

Abstract

Background/aim: Cardiovascular diseases are a leading cause of mortality and morbidity worldwide. Polymorphisms in the SCARB1 gene are known to be related to plasma lipids.

Patients And Methods: Real time-polymerase chain reaction (RT-PCR) was used for identification of SCARB1 polymorphisms and the Lipoprint Quantimetrix System was employed in identification of HDL subfractions.

Results: According to allelic distribution, in both groups SCARB1 AA genotype led to a two-fold decrease in the risk of developing cardiovascular disease (p=0.04), while the GA genotype increased the risk two-fold (p=0.03). According to the HDL subfraction analysis results, the AA genotype had higher levels of big-sized HDL subfraction (p=0.02).

Conclusion: The SCARB1AA genotype decreased cardiovascular risk and carrying GA genotype and G allele increased the risk of CAD. AA genotype carriers had higher levels of big-sized HDL subfraction.

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