Phe354Leu Polymorphism of Is a Potential Prognostic Factor for Cytogenetically Normal Acute Myeloid Leukemia

Overview

Journal In Vivo

Specialty Oncology

Date 2017 Sep 9

PMID 28882949

Citations 2

Authors

Ming-Yu Yang

Hui-Hua Hsiao

Yi-Chang Liu

Cheng-Ming Hsu

Sheng-Fung Lin

Pai-Mei Lin

Affiliations

Soon will be listed here.

Abstract

Background/aim: Liver kinase B1 (LKB1) is a major activator of the AMP-dependent kinase/mammalian target of rapamycin pathway. The prevalence and the specificity of LKB1 gene mutation in acute myeloid leukemia (AML) have not been well established. This study aimed to examine mutation of LKB1 in AML and its clinical and pathological implications.

Patients And Methods: Eighty-five patients newly diagnosed with cytogenetically normal AML were analyzed using polymerase chain reaction followed by direct sequencing.

Results: A silent mutation (837C>T) of LKB1 was detected in one patient and a pathogenic polymorphism Phe354Leu which diminishes LKB1 ability to maintain cell polarity was detected in six (7%) patients. The Phe354Leu polymorphism occurred concurrently with mutations of nucleophosmin 1 (NPM1), fms-related tyrosine kinase 3 (FLT3) and CCAAT/enhancer binding protein alpha (CEBPA), but not with metabolism-related genes, isocitrate dehydrogenase [nicotinamide adenine dinucleotide phosphate (+)]1 (IDH1) and IDH2. Patients with Phe354Leu polymorphism diagnosed at younger ages had a worse overall survival.

Conclusion: LKB1 may be involved in the leukemogenesis and progression of cytogenetically normal AML.

Citing Articles

Family Aggregation of Hematological Malignancies Discovered from an Acute Myeloid Leukemia Patient with STK11 and THBD Gene Mutation.

Zhang N, Miao X, Shuai Y, Yao H, Fan F, Liu Y Case Rep Oncol. 2023; 16(1):734-738.

PMID: 37900785 PMC: 10601766. DOI: 10.1159/000532003.

Phe354Leu polymorphism of the liver kinase B1 gene as a prognostic factor in adult egyptian patients with acute myeloid leukemia.

Hussein O, Labib H, Haggag R, Sakr M Heliyon. 2023; 9(5):e15415.

PMID: 37215763 PMC: 10192405. DOI: 10.1016/j.heliyon.2023.e15415.

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