Coordination of Chromosome Segregation and Cell Division in

Overview

Journal Front Microbiol

Specialty Microbiology

Date 2017 Sep 8

PMID 28878745

Citations 15

Authors

Amy L Bottomley

Andrew T F Liew

Kennardy D Kusuma

Elizabeth Peterson

Lisa Seidel

Simon J Foster

Elizabeth J Harry

Affiliations

Soon will be listed here.

Abstract

Productive bacterial cell division and survival of progeny requires tight coordination between chromosome segregation and cell division to ensure equal partitioning of DNA. Unlike rod-shaped bacteria that undergo division in one plane, the coccoid human pathogen divides in three successive orthogonal planes, which requires a different spatial control compared to rod-shaped cells. To gain a better understanding of how this coordination between chromosome segregation and cell division is regulated in , we investigated proteins that associate with FtsZ and the divisome. We found that DnaK, a well-known chaperone, interacts with FtsZ, EzrA and DivIVA, and is required for DivIVA stability. Unlike in several rod shaped organisms, DivIVA in associates with several components of the divisome, as well as the chromosome segregation protein, SMC. This data, combined with phenotypic analysis of mutants, suggests a novel role for DivIVA in ensuring cell division and chromosome segregation are coordinated.

Citing Articles

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Izquierdo-Martinez A, Schaper S, Brito A, Liao Q, Tesseur C, Sorg M bioRxiv. 2025; .

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PcdA promotes orthogonal division plane selection in Staphylococcus aureus.

Ramos-Leon F, Anjuwon-Foster B, Anantharaman V, Updegrove T, Ferreira C, Ibrahim A Nat Microbiol. 2024; 9(11):2997-3012.

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FtsZ and PBP4 bind to the conformationally dynamic N-terminal domain of GpsB.

Sacco M, Hammond L, Noor R, Bhattacharya D, McKnight L, Madsen J Elife. 2024; 13.

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Distinct dynamics and proximity networks of hub proteins at the prey-invading cell pole in a predatory bacterium.

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The roles of GpsB and DivIVA in growth and division.

Sutton J, Cooke M, Tinajero-Trejo M, Wacnik K, Salamaga B, Portman-Ross C Front Microbiol. 2023; 14:1241249.

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