Autophagy in Diabetic Kidney Disease: Regulation, Pathological Role and Therapeutic Potential

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2017 Sep 6

PMID 28871310

Citations 113

Authors

Danyi Yang

Man J Livingston

Zhiwen Liu

Guie Dong

Ming Zhang

Jian-Kang Chen

Zheng Dong

Affiliations

Soon will be listed here.

Abstract

Diabetic kidney disease, a leading cause of end-stage renal disease, has become a serious public health problem worldwide and lacks effective therapies. Autophagy is a highly conserved lysosomal degradation pathway that removes protein aggregates and damaged organelles to maintain cellular homeostasis. As important stress-responsive machinery, autophagy is involved in the pathogenesis of various diseases. Emerging evidence has suggested that dysregulated autophagy may contribute to both glomerular and tubulointerstitial pathologies in kidneys under diabetic conditions. This review summarizes the recent findings regarding the role of autophagy in the pathogenesis of diabetic kidney disease and highlights the regulation of autophagy by the nutrient-sensing pathways and intracellular stress signaling in this disease. The advances in our understanding of autophagy in diabetic kidney disease will facilitate the discovery of a new therapeutic target for the prevention and treatment of this life-threatening diabetes complication.

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