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Epigenetic Analysis Confirms No Accelerated Brain Aging in Schizophrenia

Overview
Journal NPJ Schizophr
Date 2017 Sep 6
PMID 28871179
Citations 27
Authors
Joanne Voisey
Bruce R Lawford
C Phillip Morris
Leesa F Wockner
Ernest P Noble
Ross McD Young
Divya Mehta
Affiliations
Soon will be listed here.
Abstract

Epigenetic aging is associated with several biological mechanisms and diseases. We assessed two brain data sets, one small (n = 48) and one large (n = 392), to test epigenetic aging in schizophrenia. DNA methylation age from frontal cortex was significantly correlated with chronological age but no significant differences in DNA methylation age acceleration between schizophrenia cases and controls were observed in both data sets. Our results were consistent with a previous study investigating schizophrenia and epigenetic aging in superior temporal gyrus. Future studies targeting different brain regions and defined cell types are warranted to further investigate accelerated brain aging in schizophrenia.

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