Transforming Growth Factor Type Beta Induces Monocyte Chemotaxis and Growth Factor Production

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1987 Aug 1

PMID 2886992

Citations 313

Authors

S M Wahl

D A Hunt

L M Wakefield

N McCartney-Francis

L M Wahl

A B Roberts

M B Sporn

Affiliations

Soon will be listed here.

Abstract

Recent studies have focused on the potential role of transforming growth factor type beta (TGF-beta) as an immunoregulatory peptide. In this context, we demonstrate that TGF-beta is a potent chemoattractant for human peripheral blood monocytes. At concentrations from 0.1 to 10 pg/ml, TGF-beta induces directed monocyte migration in vitro. Consistent with this observation is the expression of high-affinity TGF-beta receptors on the monocytes with a Kd of 1-10 pM. At higher concentrations of TGF-beta (greater than or equal to 1 ng/ml), monocytes are stimulated to generate biologically active mediator(s) that enhance fibroblast growth. Gene expression for one of these growth factors, interleukin 1, is induced in monocytes within hours after exposure to TGF-beta. Thus, TGF-beta may provide an important signal for monocyte recruitment and for regulation of their synthesis of mediators of fibroblast growth and activity in wound healing.

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References

Zigmond S, Hirsch J . Leukocyte locomotion and chemotaxis. New methods for evaluation, and demonstration of a cell-derived chemotactic factor. J Exp Med. 1973; 137(2):387-410. PMC: 2139498. DOI: 10.1084/jem.137.2.387. View

Ohura K, Katona I, Wahl L, Chenoweth D, Wahl S . Co-expression of chemotactic ligand receptors on human peripheral blood monocytes. J Immunol. 1987; 138(8):2633-9. View

Wahl S, Wahl L, McCarthy J . Lymphocyte-mediated activation of fibroblast proliferation and collagen production. J Immunol. 1978; 121(3):942-6. View

Schmidt J, Mizel S, Cohen D, Green I . Interleukin 1, a potential regulator of fibroblast proliferation. J Immunol. 1982; 128(5):2177-82. View

Deuel T, Senior R, Huang J, Griffin G . Chemotaxis of monocytes and neutrophils to platelet-derived growth factor. J Clin Invest. 1982; 69(4):1046-9. PMC: 370161. DOI: 10.1172/jci110509. View

Childs C, Proper J, Tucker R, Moses H . Serum contains a platelet-derived transforming growth factor. Proc Natl Acad Sci U S A. 1982; 79(17):5312-6. PMC: 346886. DOI: 10.1073/pnas.79.17.5312. View

Sporn M, Roberts A, Shull J, Smith J, Ward J, Sodek J . Polypeptide transforming growth factors isolated from bovine sources and used for wound healing in vivo. Science. 1983; 219(4590):1329-31. DOI: 10.1126/science.6572416. View

Roberts A, Frolik C, Anzano M, Sporn M . Transforming growth factors from neoplastic and nonneoplastic tissues. Fed Proc. 1983; 42(9):2621-6. View

Assoian R, Komoriya A, Meyers C, Miller D, Sporn M . Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization. J Biol Chem. 1983; 258(11):7155-60. View

10.

Bitterman P, Adelberg S, Crystal R . Mechanisms of pulmonary fibrosis. Spontaneous release of the alveolar macrophage-derived growth factor in the interstitial lung disorders. J Clin Invest. 1983; 72(5):1801-13. PMC: 370469. DOI: 10.1172/JCI111140. View

11.

Roberts A, Anzano M, Meyers C, Wideman J, Blacher R, Pan Y . Purification and properties of a type beta transforming growth factor from bovine kidney. Biochemistry. 1983; 22(25):5692-8. DOI: 10.1021/bi00294a002. View

12.

Wahl L, Katona I, Wilder R, WINTER C, Haraoui B, SCHER I . Isolation of human mononuclear cell subsets by counterflow centrifugal elutriation (CCE). I. Characterization of B-lymphocyte-, T-lymphocyte-, and monocyte-enriched fractions by flow cytometric analysis. Cell Immunol. 1984; 85(2):373-83. DOI: 10.1016/0008-8749(84)90251-x. View

13.

Frolik C, Wakefield L, Smith D, Sporn M . Characterization of a membrane receptor for transforming growth factor-beta in normal rat kidney fibroblasts. J Biol Chem. 1984; 259(17):10995-1000. View

14.

Polverini P, Leibovich S . Induction of neovascularization in vivo and endothelial proliferation in vitro by tumor-associated macrophages. Lab Invest. 1984; 51(6):635-42. View

15.

Smith P, Ohura K, Masur H, Lane H, Fauci A, Wahl S . Monocyte function in the acquired immune deficiency syndrome. Defective chemotaxis. J Clin Invest. 1984; 74(6):2121-8. PMC: 425403. DOI: 10.1172/JCI111637. View

16.

Baird A, Mormede P, Bohlen P . Immunoreactive fibroblast growth factor in cells of peritoneal exudate suggests its identity with macrophage-derived growth factor. Biochem Biophys Res Commun. 1985; 126(1):358-64. DOI: 10.1016/0006-291x(85)90614-x. View

17.

March C, Mosley B, Larsen A, Cerretti D, Braedt G, Price V . Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature. 1985; 315(6021):641-7. DOI: 10.1038/315641a0. View

18.

Burgess W, Mehlman T, Friesel R, JOHNSON W, Maciag T . Multiple forms of endothelial cell growth factor. Rapid isolation and biological and chemical characterization. J Biol Chem. 1985; 260(21):11389-92. View

19.

Snyderman R, Pike M . Chemoattractant receptors on phagocytic cells. Annu Rev Immunol. 1984; 2:257-81. DOI: 10.1146/annurev.iy.02.040184.001353. View

20.

Rojkind M, Valadez G . Regulation of fibroblast proliferation by Kupffer cells and monocytes. Ciba Found Symp. 1985; 114:208-21. DOI: 10.1002/9780470720950.ch14. View