Benign Esophageal Schwannoma: a Brief Overview and Our Experience with This Rare Tumor

Overview

Journal Surg Case Rep

Specialty General Surgery

Date 2017 Sep 2

PMID 28861777

Citations 8

Authors

Kazuki Moro

Masayuki Nagahashi

Kotaro Hirashima

Shin-Ichi Kosugi

Takaaki Hanyu

Hiroshi Ichikawa

Takashi Ishikawa

Gen Watanabe

Emmanuel Gabriel

Tsutomu Kawaguchi

Kazuaki Takabe

Toshifumi Wakai

Affiliations

Soon will be listed here.

Abstract

Background: Benign esophageal tumors are uncommon, comprising approximately 2% of esophageal tumors. Esophageal schwannomas constitute an even rarer entity, with few cases reported in the literature.

Case Presentation: We present a 66-year-old male who was referred for dysphagia. A computed tomography scan showed a well-demarcated, enhancing, and homogenous esophageal tumor measuring 50 mm. The tumor was hypermetabolic on positron emission tomography, and an endoscopic ultrasound-guided fine needle aspiration demonstrated the presence of benign spindle cells. We performed an uncomplicated, simple, tumor enucleation through a cervical approach. Histology revealed spindle-shaped cells in a fasciculated, disarrayed pattern. Immunohistochemistry demonstrated positive staining for S-100 protein and negative staining for KIT, CD34, desmin, and α-smooth muscle actin. These findings were consistent with a benign esophageal schwannoma.

Conclusions: We report our experience with esophageal schwannoma, a rare but benign diagnosis of the esophagus.

Citing Articles

Robotic-Assisted Minimally Invasive Resection of Multiple Oesophageal Schwannomas: A Case Report.

Menzie J, Eldredge T, Low L Cureus. 2024; 16(11):e74589.

PMID: 39735038 PMC: 11674935. DOI: 10.7759/cureus.74589.

Hybrid surgical approach for a large schwannoma from the cervical esophagus to the upper thoracic esophagus: a case report.

Nakagawa M, Mori N, Saisyo K, Yoshida T, Isobe T, Sakai H Gen Thorac Cardiovasc Surg Cases. 2024; 3(1):45.

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Total removal of a large esophageal schwannoma by submucosal tunneling endoscopic resection: A case report and review of literature.

Mu Y, Zhang Q, Zhao J, Liu Y, Kong L, Ding Z World J Clin Cases. 2023; 11(11):2510-2520.

PMID: 37123315 PMC: 10130983. DOI: 10.12998/wjcc.v11.i11.2510.

Endoscopic resection of benign esophageal schwannoma: Three case reports and review of literature.

Li B, Wang X, Zou W, Yu S, Chen Y, Xu H World J Clin Cases. 2020; 8(22):5690-5700.

PMID: 33344562 PMC: 7716328. DOI: 10.12998/wjcc.v8.i22.5690.

Clinicopathological features of esophageal schwannomas in mainland China: systematic review of the literature.

Gao Z, Liu X, Pandey S, Gao B, Liu P, Zhang Q Int J Clin Oncol. 2020; 26(2):284-295.

PMID: 33216242 DOI: 10.1007/s10147-020-01809-4.

References

Murase K, Hino A, Ozeki Y, Karagiri Y, ONITSUKA A, Sugie S . Malignant schwannoma of the esophagus with lymph node metastasis: literature review of schwannoma of the esophagus. J Gastroenterol. 2002; 36(11):772-7. DOI: 10.1007/s005350170020. View

Yibulayin W, Abulizi S, Lv H, Sun W . Minimally invasive oesophagectomy versus open esophagectomy for resectable esophageal cancer: a meta-analysis. World J Surg Oncol. 2016; 14(1):304. PMC: 5143462. DOI: 10.1186/s12957-016-1062-7. View

Tokunaga T, Takeda S, Sumimura J, Maeda H . Esophageal schwannoma: report of a case. Surg Today. 2007; 37(6):500-2. DOI: 10.1007/s00595-006-3436-x. View

Watanabe T, Miyazaki T, Saito H, Yoshida T, Kumakura Y, Honjyo H . Resection of an esophageal schwannoma with thoracoscopic surgery: a case report. Surg Case Rep. 2016; 2(1):127. PMC: 5099309. DOI: 10.1186/s40792-016-0256-0. View

Chen H, Huang H, Wu C, Lin T, Fang H . Esophageal schwannoma with tracheal compression. Thorac Cardiovasc Surg. 2006; 54(8):555-8. DOI: 10.1055/s-2006-924095. View

SEREMETIS M, LYONS W, DEGUZMAN V, PEABODY Jr J . Leiomyomata of the esophagus. An analysis of 838 cases. Cancer. 1976; 38(5):2166-77. DOI: 10.1002/1097-0142(197611)38:5<2166::aid-cncr2820380547>3.0.co;2-b. View

Asteriou C, Konstantinou D, Lalountas M, Kleontas A, Setzis K, Zafiriou G . Nine years experience in surgical approach of leiomyomatosis of esophagus. World J Surg Oncol. 2009; 7:102. PMC: 2804581. DOI: 10.1186/1477-7819-7-102. View

Choo S, Smith M, Cimino-Mathews A, Yang S . An early presenting esophageal schwannoma. Gastroenterol Res Pract. 2011; 2011:165120. PMC: 3112528. DOI: 10.1155/2011/165120. View

Wang S, Zheng J, Ruan Z, Huang H, Yang Z, Zheng J . Long-term survival in a rare case of malignant esophageal schwannoma cured by surgical excision. Ann Thorac Surg. 2011; 92(1):357-8. DOI: 10.1016/j.athoracsur.2011.01.045. View

10.

Yamao K, Sawaki A, Mizuno N, Shimizu Y, Yatabe Y, Koshikawa T . Endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNAB): past, present, and future. J Gastroenterol. 2005; 40(11):1013-23. DOI: 10.1007/s00535-005-1717-6. View

11.

Klapman J, Chang K, Wiersema M, Murata Y, Vilmann P . Endoscopic ultrasound-guided fine-needle aspiration biopsy in esophageal cancer. Endoscopy. 2005; 37(4):381-5. DOI: 10.1055/s-2005-861050. View

12.

Matsuki A, Kosugi S, Kanda T, Komukai S, Ohashi M, Umezu H . Schwannoma of the esophagus: a case exhibiting high 18F-fluorodeoxyglucose uptake in positron emission tomography imaging. Dis Esophagus. 2009; 22(4):E6-E10. DOI: 10.1111/j.1442-2050.2007.00712.x. View

13.

Mizuguchi S, Inoue K, Imagawa A, Kitano Y, Kameyama M, Ueda H . Benign esophageal schwannoma compressing the trachea in pregnancy. Ann Thorac Surg. 2008; 85(2):660-2. DOI: 10.1016/j.athoracsur.2007.07.088. View

14.

Jeon H, Kim K, Hyun K, Park J . Enucleation of giant esophageal schwannoma of the upper thoracic esophagus: reports of two cases. World J Surg Oncol. 2014; 12:39. PMC: 3936954. DOI: 10.1186/1477-7819-12-39. View

15.

Kitada M, Matsuda Y, Hayashi S, Ishibashi K, Oikawa K, Miyokawa N . Esophageal schwannoma: a case report. World J Surg Oncol. 2013; 11:253. PMC: 3851541. DOI: 10.1186/1477-7819-11-253. View

16.

Tomono A, Nakamura T, Otowa Y, Imanishi T, Tanaka Y, Maniwa Y . A Case of Benign Esophageal Schwannoma Causing Life-threatening Tracheal Obstruction. Ann Thorac Cardiovasc Surg. 2015; 21(3):289-92. PMC: 4989977. DOI: 10.5761/atcs.cr.14-00171. View

17.

von Rahden B, Stein H, Feussner H, Siewert J . Enucleation of submucosal tumors of the esophagus: minimally invasive versus open approach. Surg Endosc. 2004; 18(6):924-30. DOI: 10.1007/s00464-003-9130-9. View

18.

Park B, Carrasquillo J, Bains M, Flores R . Giant benign esophageal schwannoma requiring esophagectomy. Ann Thorac Surg. 2006; 82(1):340-2. DOI: 10.1016/j.athoracsur.2005.09.042. View

19.

Akaogi E, Mitsui K, Sohara Y, Endo S, Ishikawa S, Hori M . Treatment of postoperative chylothorax with intrapleural fibrin glue. Ann Thorac Surg. 1989; 48(1):116-8. DOI: 10.1016/0003-4975(89)90193-8. View

20.

Kinoshita K, Isozaki K, Tsutsui S, Kitamura S, Hiraoka S, Watabe K . Endoscopic ultrasonography-guided fine needle aspiration biopsy in follow-up patients with gastrointestinal stromal tumours. Eur J Gastroenterol Hepatol. 2003; 15(11):1189-93. DOI: 10.1097/00042737-200311000-00007. View