Muscle-Bone Interactions in Pediatric Bone Diseases

Overview

Journal Curr Osteoporos Rep

Publisher Current Science

Specialties Endocrinology
Orthopedics

Date 2017 Sep 1

PMID 28856575

Citations 18

Authors

Louis-Nicolas Veilleux

Frank Rauch

Affiliations

Soon will be listed here.

Abstract

Purpose: Here, we review the skeletal effects of pediatric muscle disorders as well as muscle impairment in pediatric bone disorders.

Recent Findings: When starting in utero, muscle disorders can lead to congenital multiple contractures. Pediatric-onset muscle weakness such as cerebral palsy, Duchenne muscular dystrophy, spinal muscular atrophy, or spina bifida typically are associated with small diameter of long-bone shafts, low density of metaphyseal bone, and increased fracture incidence in the lower extremities, in particular, the distal femur. Primary bone diseases can affect muscles through generic mechanisms, such as decreased physical activity or in disease-specific ways. For example, the collagen defect underlying the bone fragility of osteogenesis imperfecta may also affect muscle force generation or transmission. Transforming growth factor beta released from bone in Camurati Engelman disease may decrease muscle function.

Future Directions: Considering muscle-bone interactions does not only contribute to the understanding of musculoskeletal disorders but also can identify new targets for therapeutic interventions.

Citing Articles

Low muscle density in children with osteogenesis imperfecta using opportunistic low-dose chest CT: a case-control study.

Yuan Y, Xu Y, Feng C, Liu Y, Zhang W, Huang P BMC Musculoskelet Disord. 2024; 25(1):478.

PMID: 38890605 PMC: 11184700. DOI: 10.1186/s12891-024-07596-7.

The BALB/c.mdx62 mouse exhibits a dystrophic muscle pathology and is a model of Duchenne muscular dystrophy.

Swiderski K, Chan A, Herold M, Kueh A, Chung J, Hardee J Dis Model Mech. 2024; 17(4).

PMID: 38602028 PMC: 11095634. DOI: 10.1242/dmm.050502.

Bone Health Status of Children with Spinal Muscular Atrophy.

Tung J, Chow T, Wai M, Lo J, Chan S J Bone Metab. 2023; 30(4):319-327.

PMID: 38073265 PMC: 10721381. DOI: 10.11005/jbm.2023.30.4.319.

Compromised Muscle Properties in a Severe Hypophosphatasia Murine Model.

Pendleton E, Nichenko A, Mcfaline-Figueroa J, Raymond-Pope C, Schifino A, Pigg T Int J Mol Sci. 2023; 24(21).

PMID: 37958888 PMC: 10649932. DOI: 10.3390/ijms242115905.

Enhanced contrast synchrotron X-ray microtomography for describing skeleton-associated soft tissue defects in zebrafish mutants.

Leyhr J, Sanchez S, Dollman K, Tafforeau P, Haitina T Front Endocrinol (Lausanne). 2023; 14:1108916.

PMID: 36950679 PMC: 10025580. DOI: 10.3389/fendo.2023.1108916.

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