Dynamic Contrast-enhanced and Diffusion-weighted MR Imaging in the Characterisation of Small, Non-palpable Solid Testicular Tumours

Overview

Journal Eur Radiol

Specialty Radiology

Date 2017 Sep 1

PMID 28856410

Citations 16

Authors

Lucia Manganaro

Matteo Saldari

Carlotta Pozza

Valeria Vinci

Daniele Gianfrilli

Ermanno Greco

Giorgio Franco

Maria Eleonora Sergi

Michele Scialpi

Carlo Catalano

Andrea M Isidori

Affiliations

Soon will be listed here.

Abstract

Objectives: To explore the role of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), using semiquantitative and quantitative parameters, and diffusion-weighted (DW) MRI in differentiating benign from malignant small, non-palpable solid testicular tumours.

Methods: We calculated the following DCE-MRI parameters of 47 small, non-palpable solid testicular tumours: peak enhancement (PE), time to peak (TTP), percentage of peak enhancement (Epeak), wash-in-rate (WIR), signal enhancement ratio (SER), volume transfer constant (K), rate constant (K), extravascular extracellular space volume fraction (V) and initial area under the curve (AUC). DWI signal intensity and apparent diffusion coefficient (ADC) values were evaluated.

Results: E, WIR, K , K and iAUC were higher and TTP shorter in benign compared to malignant lesions (p < 0.05). All tumours had similar ADC values (p > 0.07). Subgroup analysis limited to the most frequent histologies - Leydig cell tumours (LCTs) and seminomas - replicated the findings of the entire set. Best diagnostic cutoff value for identification of seminomas: K ≤0.135 min, K ≤0.45 min, iAUC ≤10.96, WIR ≤1.11, Epeak ≤96.72, TTP >99 s.

Conclusions: DCE-MRI parameters are valuable in differentiating between benign and malignant small, non-palpable testicular tumours, especially when characterising LCTs and seminomas.

Key Points: • DCE-MRI may be used to differentiate benign from malignant non-palpable testicular tumours. • Seminomas show lower Ktrans, Kep and iAUC values. • ADC values are not valuable in differentiating seminomas from LCTs. • Semiquantitative DCE-MRI may be used to characterise small, solid testicular tumours.

Citing Articles

Utility of diffusion weighted Magnetic Resonance Imagining to detect non-palpable undescended testis.

Naz N, Walid A, Rahim A, Lajpat K Pak J Med Sci. 2024; 40(9):2069-2073.

PMID: 39416622 PMC: 11476170. DOI: 10.12669/pjms.40.9.8905.

Discriminating Malignant from Benign Testicular Masses Using Multiparametric Magnetic Resonance Imaging-A Prospective Single-Center Study.

Torzsok P, Deininger S, Abenhardt M, Oswald D, Lusuardi L, Deininger C J Clin Med. 2024; 13(15).

PMID: 39124657 PMC: 11313008. DOI: 10.3390/jcm13154390.

Diagnosis and management of indeterminate testicular lesions.

Croghan S, Malak J, Rohan P, Byrne C, McGrath A, Cullen I Nat Rev Urol. 2023; 21(1):7-21.

PMID: 37414958 DOI: 10.1038/s41585-023-00786-3.

An Overview of the Role of Multiparametric MRI in the Investigation of Testicular Tumors.

Tsili A, Sofikitis N, Pappa O, Bougia C, Argyropoulou M Cancers (Basel). 2022; 14(16).

PMID: 36010905 PMC: 9405843. DOI: 10.3390/cancers14163912.

Leydig Cell Tumors of the Testis: An Update of the Imaging Characteristics of a Not So Rare Lesion.

Maxwell F, Savignac A, Bekdache O, Calvez S, Lebacle C, Arama E Cancers (Basel). 2022; 14(15).

PMID: 35954321 PMC: 9367522. DOI: 10.3390/cancers14153652.

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