Analysis of Glycinamide Ribonucleotide Transformylase Inhibition by PY873, PY899 and DIA

Overview

Journal Saudi J Biol Sci

Specialty Biology

Date 2017 Sep 1

PMID 28855807

Citations 4

Authors

Sidra Batool

Muhammad Sulaman Nawaz

Gohar Mushtaq

Fahed Parvaiz

Mohammad A Kamal

Affiliations

Soon will be listed here.

Abstract

In humans, purine synthesis pathway consists of multi-functional enzymes. Nucleotide metabolism enzymes are potential drug targets for treating cancer and autoimmune diseases. Glycinamide ribonucleotide transformylase (GART) is one of the most important trifunctional enzymes involved in purine synthesis. Previous studies have demonstrated the role of folate inhibitors against tumor activity. In this present study, three components of GART enzyme were targeted as receptor dataset and analysis was carried out with folate ligand dataset. To accomplish the task, Autodock 4.2 was used for determining the docking compatibilities of ligand and receptor dataset. Taken together, it has been suggested that folate ligands could be potentially used as inhibitors of GART.

Citing Articles

The Intersection of Purine and Mitochondrial Metabolism in Cancer.

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Targeting Future Pandemics, a Case for Purine Synthesis and Basic Research.

Mazzarino R Front Immunol. 2021; 12:694300.

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PAICS, a Purine Nucleotide Metabolic Enzyme, is Involved in Tumor Growth and the Metastasis of Colorectal Cancer.

Agarwal S, Chakravarthi B, Behring M, Kim H, Chandrashekar D, Gupta N Cancers (Basel). 2020; 12(4).

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One-carbon metabolism and nucleotide biosynthesis as attractive targets for anticancer therapy.

Shuvalov O, Petukhov A, Daks A, Fedorova O, Vasileva E, Barlev N Oncotarget. 2017; 8(14):23955-23977.

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