Noncoding RNAs in Neurodegeneration

Overview

Journal Nat Rev Neurosci

Specialty Neurology

Date 2017 Sep 1

PMID 28855739

Citations 88

Authors

Evgenia Salta

Bart De Strooper

Affiliations

Soon will be listed here.

Abstract

The emerging complexity of the transcriptional landscape poses great challenges to our conventional preconceptions of how the genome regulates brain function and dysfunction. Non-protein-coding RNAs (ncRNAs) confer a high level of intricate and dynamic regulation of various molecular processes in the CNS and they have been implicated in neurodevelopment and brain ageing, as well as in synapse function and cognitive performance, in both health and disease. ncRNA-mediated processes may be involved in various aspects of the pathogenesis of neurodegenerative disorders. Understanding these events may help to develop novel diagnostic and therapeutic tools. Here, we provide an overview of the complex mechanisms that are affected by the diverse ncRNA classes that have been implicated in neurodegeneration.

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References

Wahlestedt C . Targeting long non-coding RNA to therapeutically upregulate gene expression. Nat Rev Drug Discov. 2013; 12(6):433-46. DOI: 10.1038/nrd4018. View

Leone S, Santoro R . Challenges in the analysis of long noncoding RNA functionality. FEBS Lett. 2016; 590(15):2342-53. DOI: 10.1002/1873-3468.12308. View

Ferre F, Colantoni A, Helmer-Citterich M . Revealing protein-lncRNA interaction. Brief Bioinform. 2015; 17(1):106-16. PMC: 4719072. DOI: 10.1093/bib/bbv031. View

Yang Y, Wen L, Zhu H . Unveiling the hidden function of long non-coding RNA by identifying its major partner-protein. Cell Biosci. 2015; 5:59. PMC: 4618879. DOI: 10.1186/s13578-015-0050-x. View

Ambrosi G, Ghezzi C, Sepe S, Milanese C, Payan-Gomez C, Bombardieri C . Bioenergetic and proteolytic defects in fibroblasts from patients with sporadic Parkinson's disease. Biochim Biophys Acta. 2014; 1842(9):1385-94. DOI: 10.1016/j.bbadis.2014.05.008. View

Carrieri C, Forrest A, Santoro C, Persichetti F, Carninci P, Zucchelli S . Expression analysis of the long non-coding RNA antisense to Uchl1 (AS Uchl1) during dopaminergic cells' differentiation in vitro and in neurochemical models of Parkinson's disease. Front Cell Neurosci. 2015; 9:114. PMC: 4381646. DOI: 10.3389/fncel.2015.00114. View

Graur D, Zheng Y, Price N, Azevedo R, Zufall R, Elhaik E . On the immortality of television sets: "function" in the human genome according to the evolution-free gospel of ENCODE. Genome Biol Evol. 2013; 5(3):578-90. PMC: 3622293. DOI: 10.1093/gbe/evt028. View

Somel M, Liu X, Khaitovich P . Human brain evolution: transcripts, metabolites and their regulators. Nat Rev Neurosci. 2013; 14(2):112-27. DOI: 10.1038/nrn3372. View

Nelson P, Wang W, Partch A, Monsell S, Valladares O, Ellingson S . Reassessment of risk genotypes (GRN, TMEM106B, and ABCC9 variants) associated with hippocampal sclerosis of aging pathology. J Neuropathol Exp Neurol. 2014; 74(1):75-84. PMC: 4270894. DOI: 10.1097/NEN.0000000000000151. View

10.

Xu L, Zhang Z, Xie T, Zhang X, Dai T . Inhibition of BDNF-AS Provides Neuroprotection for Retinal Ganglion Cells against Ischemic Injury. PLoS One. 2016; 11(12):e0164941. PMC: 5147780. DOI: 10.1371/journal.pone.0164941. View

11.

DeVos S, Miller T . Antisense oligonucleotides: treating neurodegeneration at the level of RNA. Neurotherapeutics. 2013; 10(3):486-97. PMC: 3701770. DOI: 10.1007/s13311-013-0194-5. View

12.

Coulson E, Paliga K, Beyreuther K, Masters C . What the evolution of the amyloid protein precursor supergene family tells us about its function. Neurochem Int. 2000; 36(3):175-84. DOI: 10.1016/s0197-0186(99)00125-4. View

13.

Lipovich L, Dachet F, Cai J, Bagla S, Balan K, Jia H . Activity-dependent human brain coding/noncoding gene regulatory networks. Genetics. 2012; 192(3):1133-48. PMC: 3522156. DOI: 10.1534/genetics.112.145128. View

14.

Zhang B, Wang A, Xia C, Lin Q, Chen C . A single nucleotide polymorphism in primary-microRNA-146a reduces the expression of mature microRNA-146a in patients with Alzheimer's disease and is associated with the pathogenesis of Alzheimer's disease. Mol Med Rep. 2015; 12(3):4037-4042. PMC: 4526084. DOI: 10.3892/mmr.2015.3968. View

15.

Mus E, Hof P, Tiedge H . Dendritic BC200 RNA in aging and in Alzheimer's disease. Proc Natl Acad Sci U S A. 2007; 104(25):10679-84. PMC: 1965572. DOI: 10.1073/pnas.0701532104. View

16.

DeVos S, Miller T . Direct intraventricular delivery of drugs to the rodent central nervous system. J Vis Exp. 2013; (75):e50326. PMC: 3679837. DOI: 10.3791/50326. View

17.

Roberts T, Morris K, Wood M . The role of long non-coding RNAs in neurodevelopment, brain function and neurological disease. Philos Trans R Soc Lond B Biol Sci. 2014; 369(1652). PMC: 4142028. DOI: 10.1098/rstb.2013.0507. View

18.

Packer A, Xing Y, Harper S, Jones L, Davidson B . The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington's disease. J Neurosci. 2009; 28(53):14341-6. PMC: 3124002. DOI: 10.1523/JNEUROSCI.2390-08.2008. View

19.

Faghihi M, Modarresi F, Khalil A, Wood D, Sahagan B, Morgan T . Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase. Nat Med. 2008; 14(7):723-30. PMC: 2826895. DOI: 10.1038/nm1784. View

20.

Stahl P, Salmen F, Vickovic S, Lundmark A, Fernandez Navarro J, Magnusson J . Visualization and analysis of gene expression in tissue sections by spatial transcriptomics. Science. 2016; 353(6294):78-82. DOI: 10.1126/science.aaf2403. View