A Novel Sex-linked Mutant Affecting Tail Formation in Hongshan Chicken

Overview

Journal Sci Rep

Specialty Science

Date 2017 Sep 1

PMID 28855651

Citations 5

Authors

Qiong Wang

Jinsong Pi

Ailuan Pan

Jie Shen

Lujiang Qu

Affiliations

Soon will be listed here.

Abstract

The Hongshan chicken is a Chinese indigenous breed that has two distinctly different tail types. Some chickens have stunted tails as compared to the normal phenotype, and they are termed rumpless. Rumplessness in other chicken breeds was caused by a reduction in the number of coccygeal vertebrae. However, X-ray examination showed that rumpless Hongshan chickens possess the normal number of coccygeal vertebrae. Our analyses of the main tail feathers and tissue sections led us to speculate that their stunted tail appearance may be the result of abnormal feather development. To investigate the genetic mechanism underlying rumplessness in Hongshan chickens, we analyzed the results of various crosses. The results indicated that rumplessness is a Z-linked dominant character. In addition, we chose some normal and rumpless individuals for pool-sequencing. Nucleotide diversity and Fst were calculated, and a selective sweep was detected on the Z chromosome. These analyses allowed us to reduce the search area to 71.8-72 Mb on the Z chromosome (galGal5.0). A pseudogene LOC431648 located in this region appeared a strong candidate involving in Wnt/β-catenin signaling pathway to regulate feather development in chickens.

Citing Articles

Molecular genetic foundation of a sex-linked tailless trait in Hongshan chicken by whole genome data analysis.

Chen A, Wang Q, Zhao X, Wang G, Zhang X, Ren X Poult Sci. 2024; 103(6):103685.

PMID: 38603937 PMC: 11017342. DOI: 10.1016/j.psj.2024.103685.

Mapping and Functional Dissection of the Rumpless Trait in Piao Chicken Identifies a Causal Loss of Function Mutation in the Novel Gene Rum.

Guo Y, Tian J, Song C, Han W, Zhu C, Li H Mol Biol Evol. 2023; 40(12).

PMID: 38069902 PMC: 10735294. DOI: 10.1093/molbev/msad273.

Phenotypic Analysis of Growth and Morphological Traits in Miniature Breeds of Japanese Indigenous Chickens.

Ono R, Miyachi H, Usui H, Oguchi R, Nishimura K, Takahashi K J Poult Sci. 2022; 59(1):38-47.

PMID: 35125911 PMC: 8791770. DOI: 10.2141/jpsa.0200110.

Genomic Regions Related to White/Black Tail Feather Color in Dwarf Chickens Identified Using a Genome-Wide Association Study.

Nie C, Qu L, Li X, Jiang Z, Wang K, Li H Front Genet. 2021; 12:566047.

PMID: 33995468 PMC: 8120320. DOI: 10.3389/fgene.2021.566047.

Integrating Genomic and Transcriptomic Data to Reveal Genetic Mechanisms Underlying Piao Chicken Rumpless Trait.

Wang Y, Khederzadeh S, Li S, Otecko N, Irwin D, Thakur M Genomics Proteomics Bioinformatics. 2021; 19(5):787-799.

PMID: 33631431 PMC: 9170765. DOI: 10.1016/j.gpb.2020.06.019.

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