Prognostic Factors Indicating Survival with Native Liver After Kasai Procedure for Biliary Atresia

Overview

Journal Pediatr Surg Int

Specialties General Surgery
Pediatrics

Date 2017 Aug 31

PMID 28852838

Citations 4

Authors

Juma Obayashi

Kohei Kawaguchi

Shutaro Manabe

Hideki Nagae

Munechika Wakisaka

Junki Koike

Masayuki Takagi

Hiroaki Kitagawa

Affiliations

Soon will be listed here.

Abstract

Background: The number of the bile ducts in the portal canal/measured surface area of the portal canal (BDP ratio) indicates prognosis in biliary atresia (BA), as does an elevated cytokeratin 7 positivity percentage (PCK7). We compared these two markers.

Methods: We reviewed 32 BA cases undergoing Kasai operation from 1976 to 2016 with >5 portal canals in biopsy samples. Group I required liver transplantation or died within a year of operation (n = 8). Group II survived with their native liver (n = 24). We determined the BDP ratio (10/mm) and PCK7 (%), subdividing patients into three groups by their age at operation: Group A ≤60 days (n = 6, 1 Group I), 60< Group B ≤90days (n = 16, 5 Group I), Group C >90 days (n = 10, 2 Group I).

Results: PCK7 (%) was 2.71 ± 1.87 in Group I and 4.25 ± 2.56 in Group II (p = 0.13). BDP ratio (10/mm) was 1.19 ± 0.424 in Group I and 1.64 ± 0.534 in Group II (p = 0.04). Both markers were higher in Group C than in Group A or B (p < 0.01).

Conclusion: The BDP ratio is a better prognostic indicator than PCK7 in BA.

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