Decreased Microvascular Function in Tanzanian Children With Severe and Uncomplicated Falciparum Malaria

Overview

Journal Open Forum Infect Dis

Specialty Infectious Diseases

Date 2017 Aug 31

PMID 28852670

Citations 4

Authors

Tsin W Yeo

Salvatore M Florence

Ayam R Kalingonji

Youwei Chen

Donald L Granger

Nicholas M Anstey

Esther D Mwaikambo

J Brice Weinberg

Affiliations

Soon will be listed here.

Abstract

Microvascular function and oxygen consumption affect oxygen homeostasis but have not been assessed in African children with malaria. Microvascular function in Tanzanian children with severe malaria (SM) or uncomplicated malaria were 39% and 72%, respectively, of controls ( < .001). Uncomplicated malaria ( = .04), not SM ( = .06), children had increased oxygen consumption compared with controls.

Citing Articles

Vascular Dysfunction in Malaria: Understanding the Role of the Endothelial Glycocalyx.

Bush M, Anstey N, Yeo T, Florence S, Granger D, Mwaikambo E Front Cell Dev Biol. 2021; 9:751251.

PMID: 34858979 PMC: 8631294. DOI: 10.3389/fcell.2021.751251.

Degradation of endothelial glycocalyx in Tanzanian children with falciparum malaria.

Bush M, Florence S, Yeo T, Kalingonji A, Chen Y, Granger D FASEB J. 2021; 35(9):e21805.

PMID: 34403544 PMC: 8375618. DOI: 10.1096/fj.202100277RR.

Glycocalyx breakdown is increased in African children with cerebral and uncomplicated falciparum malaria.

Yeo T, Bush P, Chen Y, Young S, Zhang H, Millington D FASEB J. 2019; 33(12):14185-14193.

PMID: 31658834 PMC: 6894053. DOI: 10.1096/fj.201901048RR.

The Plasmodium falciparum transcriptome in severe malaria reveals altered expression of genes involved in important processes including surface antigen-encoding var genes.

Tonkin-Hill G, Trianty L, Noviyanti R, Nguyen H, Sebayang B, Lampah D PLoS Biol. 2018; 16(3):e2004328.

PMID: 29529020 PMC: 5864071. DOI: 10.1371/journal.pbio.2004328.

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