Is Plasma GABA of Peripheral Origin?
Overview
Affiliations
Plasma levels of gamma-aminobutyric acid (GABA) appear to be altered in affective disorders and alcoholism. Plasma levels of GABA were not affected by menstrual cycle, exercise, gender, gut flora, nor by cholinergic stimulation by bethanechol. An obvious peripheral source for plasma GABA could not be demonstrated.
The role of GABA in type 1 diabetes.
Mick G, McCormick K Front Endocrinol (Lausanne). 2024; 15:1453396.
PMID: 39619323 PMC: 11604429. DOI: 10.3389/fendo.2024.1453396.
Hernandez L, Betancourt L, Nakayasu E, Ansong C, Ceballos G, Paredes D Int J Mol Sci. 2021; 22(16).
PMID: 34445459 PMC: 8395897. DOI: 10.3390/ijms22168754.
Effect of oral γ-aminobutyric acid (GABA) administration on sleep and its absorption in humans.
Yamatsu A, Yamashita Y, Pandharipande T, Maru I, Kim M Food Sci Biotechnol. 2018; 25(2):547-551.
PMID: 30263304 PMC: 6049207. DOI: 10.1007/s10068-016-0076-9.
Deligiannidis K, Kroll-Desrosiers A, Mo S, Nguyen H, Svenson A, Jaitly N Psychoneuroendocrinology. 2016; 70:98-107.
PMID: 27209438 PMC: 4907817. DOI: 10.1016/j.psyneuen.2016.05.010.
Study of GABA in Healthy Volunteers: Pharmacokinetics and Pharmacodynamics.
Li J, Zhang Z, Liu X, Wang Y, Mao F, Mao J Front Pharmacol. 2015; 6:260.
PMID: 26617516 PMC: 4639630. DOI: 10.3389/fphar.2015.00260.